| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Small cell lung cancer | H69 | Up | WWOX | ERK pathway | MicroRNA-134 regulates cell proliferation and inhibits apoptosis through the activation of ERK1/2 pathway. | Chen et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | ITGB1 | ITGB1 pathway | MicroRNA-134 significantly suppresses hepatocellular carcinoma cell invasion and metastasis by targeting integrin beta-1. miR-134 also suppresses the phosphorylation of focal adhesion kinase and the activation of RhoA downstream of the ITGB1 pathway, thereby inhibiting stress fiber formation and cell adhesion in hepatocellular carcinoma cells. | Zha et al., 2014 |