| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Stomach | Up | AP 2 ALPHA | BCL-2 pathway | MicroRNA-135a enhances BCL-2 through AP-2-alpha and consequently increases cell resistance to apoptosis. | Pan et al., 2014 |
| Cervical cancer | HeLa, Ca Ski, SiHa | Up | SIAH1 | Beta-catenin pathway | MicroRNA-135a promotes cervical cancer cell transformation via regulating miR-135a/SIAH1/beta-catenin signaling pathway. | Leung et al., 2014 |
| Prostate cancer | PC-3, DU145 | Down | EGFR | EGFR signaling pathway | Hsa-miR-135a-1 suppresses cell growth and migration of prostate cancer by down-regulating EGFR expression. | Xu et al., 2016 |