Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Nasal natural killer cell lymphoma | YT, NK-92 | Up | RICTOR | PI3K-Akt signaling pathway | hsa-miR-142 suppresses the expression of RICTOR with secondary inhibition of AKT. The PI3K-Akt signaling pathway is critical in the pathogenesis of Nasal natural killer cell lymphoma. | Chen et al., 2015 |
Breast cancer | MCF-7, MDA-MB-231 | Up | APC | Wnt signaling pathway | MicroRNA-142 regulates human breast cancer stem cell properties through activation of the Wnt signaling pathway. | Isobe et al., 2014 |