microRNA Name:

hsa-miR-146a

Gene Score: 0.0274

Pathway Score: 0.0738

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Alzheimer's disease SH-SY5Y Up LRP2 PI3K-Akt signaling pathway Upregulation of miRNA-146a significantly suppresses Lrp2 ( Low-density lipoprotein receptor-related protein-2) expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby enhancing cell apoptosis.
Zhang et al., 2016
Hepatitis C virus infection Peripheral blood monocyte Up Toll-like receptor signaling pathway MicroRNA-146a expression is abnormally enhanced in peripheral blood monocytes of HCV-infected patients. The Toll-like receptor signaling pathway takes part in the upregulation of miR-146a in monocytes stimulated with HCV core protein.
Zhang et al., 2015
Hepatitis C virus infection Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-146a by modulating Toll-like receptor signaling pathway.
El-Ekiaby et al., 2012
Gastric cancer HGC-27, HeLa, GES-1, U2OS Up FANCM Fanconi Anemia pathway MicroRNA-146a down-regulates the expression of FANCM, a component in the Fanconi Anemia pathway.
Sundaravinayagam et al., 2016
Gastric cancer SNU-638 Up COPS8 GPCR pathway Upregulation of miR-146a down-regulates expression of COPS8, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors.
Crone et al., 2012
Gastric cancer SNU-638 Up CARD10 GPCR pathway Upregulation of miR-146a down-regulates expression of CARD10, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors.
Crone et al., 2012
Non-small cell lung cancer Lung Down MIF NF-Kappa B signaling pathway Overexpression of miR-146a suppresses the expression of MIF and promotes the apoptosis of cancer cells via NF-Kappa B signaling pathway.
Wang et al., 2016
Breast cancer MCF-7 CXCR4 NF-Kappa B signaling pathway Down-regulation of microRNA-146a is associated with increased expression of CXCR4, TRAF6 and EGFR which further activates NF-Kappa B signaling pathway and enhances the proliferation, migration, invasion and anti-apoptotic activity.
Zheng et al., 2015
Prostate cancer Prostate Down ROCK1 ROCK pathway MicroRNA-146a plays an important role in the process of androgen-independent prostate cancer cells apoptosis through regulation of ROCK pathway.
Xu et al., 2015