Alzheimer's disease |
SH-SY5Y |
Up |
LRP2 |
PI3K-Akt signaling pathway |
Upregulation of miRNA-146a significantly suppresses Lrp2 ( Low-density lipoprotein receptor-related protein-2) expression, resulting in a reduction of Akt activation and induction of proapoptotic caspase-3, thereby enhancing cell apoptosis. |
Zhang et al., 2016 |
Hepatitis C virus infection |
Peripheral blood monocyte |
Up |
|
Toll-like receptor signaling pathway |
MicroRNA-146a expression is abnormally enhanced in peripheral blood monocytes of HCV-infected patients. The Toll-like receptor signaling pathway takes part in the upregulation of miR-146a in monocytes stimulated with HCV core protein. |
Zhang et al., 2015 |
Hepatitis C virus infection |
Peripheral blood mononuclear cells |
Down |
|
Toll-like receptor signaling pathway |
HCV infection suppresses the induction of miR-146a by modulating Toll-like receptor signaling pathway. |
El-Ekiaby et al., 2012 |
Gastric cancer |
HGC-27, HeLa, GES-1, U2OS |
Up |
FANCM |
Fanconi Anemia pathway |
MicroRNA-146a down-regulates the expression of FANCM, a component in the Fanconi Anemia pathway. |
Sundaravinayagam et al., 2016 |
Gastric cancer |
SNU-638 |
Up |
COPS8 |
GPCR pathway |
Upregulation of miR-146a down-regulates expression of COPS8, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors. |
Crone et al., 2012 |
Gastric cancer |
SNU-638 |
Up |
CARD10 |
GPCR pathway |
Upregulation of miR-146a down-regulates expression of CARD10, inhibiting GPCR-mediated activation of NF-kappaB, thus decreasing expression of NF-kappa B-regulated tumor-promoting cytokines and growth factors. |
Crone et al., 2012 |
Non-small cell lung cancer |
Lung |
Down |
MIF |
NF-Kappa B signaling pathway |
Overexpression of miR-146a suppresses the expression of MIF and promotes the apoptosis of cancer cells via NF-Kappa B signaling pathway. |
Wang et al., 2016 |
Breast cancer |
MCF-7 |
|
CXCR4 |
NF-Kappa B signaling pathway |
Down-regulation of microRNA-146a is associated with increased expression of CXCR4, TRAF6 and EGFR which further activates NF-Kappa B signaling pathway and enhances the proliferation, migration, invasion and anti-apoptotic activity. |
Zheng et al., 2015 |
Prostate cancer |
Prostate |
Down |
ROCK1 |
ROCK pathway |
MicroRNA-146a plays an important role in the process of androgen-independent prostate cancer cells apoptosis through regulation of ROCK pathway. |
Xu et al., 2015 |