microRNA Name:

hsa-miR-15

Gene Score: 0.003

Pathway Score: 0.0082

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Diffuse Large B-cell lymphoma Ly1, Ly3, Ly10, Ly18, Ly19 Up SMAD5 TGF-beta signaling pathway Overexpression of hsa-miR-155 downregulates the expression of SMAD5, establishing a link between this miRNA, the TGF-beta signaling pathway, and lymphomagenesis.
 Rai et al., 2010
Diffuse Large B-cell lymphoma CRL2631 Up PIK3R1 PI3K-Akt signaling pathway Overexpression of miR-155 activates PI3K-Akt signaling pathway through regulating PIK3R1 in in diffuse large B-cell lymphoma.
 Huang et al., 2012
Malignant lymphoma Lymphoma cell lines Down DKC1 PI3K-Akt signaling pathway miR-150 directly targets DKC1, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
Malignant lymphoma Lymphoma cell lines Down AKT PI3K-Akt signaling pathway miR-150 directly targets AKT2, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells.
 Watanabe et al., 2011
T-cell acute lymphoblastic leukemia MOLT-3, Jurkat, CCRF-HSB-2 Up NOTCH3 Notch signaling pathway Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia.
 Ghisi et al., 2011
Chronic lymphocytic leukemia MEC-2, BJAB Up QKI LPS signaling pathway miR-155 down-regulates expression of QKI at the onset of immune response to LPS. Overexpression of QKI increases IL-10 production, as well as the total amount of p38, while markedly impairing p38 phosphorylation.
 Tili et al., 2015
Chronic lymphocytic leukemia Peripheral blood Down MCL1 MCL1 pathway p53 deletion results in a decrease of miR-15a, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia.
 Liu et al., 2014
B-cell chronic lymphocytic leukemia Peripheral blood Down TP53 p53 signaling pathway Over-expression of hsa-miR-15a suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis.
 Fabbri et al, 2011
Chronic lymphocytic leukemia Peripheral blood Down BCL2 Apoptosis pathway miR-15a downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia.
 Cimmino et al., 2005
Parkinson's disease HEK293 Up ALPHA SYNUCLEIN mTOR pathway MicroRNA-153 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.
 Fragkouli et al., 2014
Parkinson's disease SH-SY5Y Up NRF2 Nrf2 signaling pathway MicroRNA-153 directly targets Nrf2-antioxidant network which results an aberrant cellular survival events.
 Narasimhan et al., 2014
Post influenza bacterial pneumonia - Up IL-17 signaling pathway MicroRNA-155 controls host immune response to postviral bacterial pneumonia through IL-23/IL-17 pathway.
 Podsiad et al., 2016
Hepatitis C virus infection Hepatocyte Up APC Wnt signaling pathway Over-expression of microRNA-155 promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling pathway.
Zhang et al., 2012
Hepatitis C virus infection Peripheral blood mononuclear cells Down Toll-like receptor signaling pathway HCV infection suppresses the induction of miR-155 by modulating Toll-like receptor signaling pathway.
 El-Ekiaby et al., 2012
Gastric cancer SC-M1, AGS, NUGC-3, SNU-16, AZ-521, KATO III Up P53 Notch signaling pathway Notch1/miR-151-5p axis regulates the progression of gastric cancer cells through targeting p53.
 Hsu et al., 2016
Non-small cell lung cancer A-549 TLR1 NF-Kappa B signaling pathway MicroRNA-15a increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1.
 Lan et al., 2015
Hepatocellular carcinoma BEL-7402, Hep-G2, SMMC-7721 Up ARID2 PI3K-Akt signaling pathway MicroRNA-155 enhances tumor growth in hepatocellular carcinoma by inhibiting ARID2-mediated Akt phosphorylation pathway.
 Zhang et al., 2016
Breast cancer MCF-7, SK-BR-3 Up SOCS6 Jak-STAT signaling pathway MicroRNA-155 promotes TAM resistance in breast cancer by regulating SOCS6-STAT3 signaling pathway.
 Shen et al., 2015
Ovarian cancer SK-OV-3, SNU-119 PI3K-Akt signaling pathway Decreased expression of miRNA-150 enhances pertuzumab resistance in ovarian cancer cells through AKT activation.
 Wuerkenbieke et al., 2015
Breast cancer MCF-7 Up MAPK signaling pathway Upregulation of microRNA-155 enhances tumorigenesis through modulating mitogen activated protein kinase signaling pathway.
 Martin et al., 2014
Hepatocellular carcinoma Hepatocyte Up WWOX Wnt signaling pathway Overexpression of hsa-miR-153 downregulates WWOX, a tumor suppressor and inhibitor of Wnt signaling pathway in hepatocellular carcinoma.
 Hua et al., 2015
Ovarian cancer SK-OV-3, SNU-119 Down PI3K-Akt signaling pathway Decreased expression of miRNA-150 regulates the pertuzumab resistance in ovarian cancer through PI3K-Akt signaling pathway.
 Wuerkenbieke et al., 2015
Bladder cancer UM-UC-3, T24 Up DMTF1 p53 signaling pathway MicroRNA-155 acts as a tumor promoter by inhibiting DMTF1 expression in bladder cancer.
 Peng et al., 2015
Myocarditis Myocardial Up REL A NF-Kappa B signaling pathway hsa-miR-155 reduces cardiac injury by repressing NF-Kappa B signaling pathway during acute viral myocarditis.
 Bao et al., 2014
Heart failure Left ventricular Up TGFBR1 TGF-beta signaling pathway Overexpression of hsa-miR-15 inhibits TGF-beta signaling pathway through downregulating the expression of TGFBR1.
 Tijsen et al., 2014
Psoriasis HaCat Up PTEN PTEN pathway Decreased expression of miR-155 significantly inhibits proliferation, migration, invasion and promotes apoptosis through PTEN singaling pathway in psoriasis cells.
 Xu et al., 2017
Psoriasis HaCat Up AKT PTEN pathway MicroRNA-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis. Expression of apoptosis related factor AKT is dramatically changed.
 Xu et al., 2017
Psoriasis HaCat Up BCL 2 PTEN pathway Hsa-miR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway through targeting BCL 2 in the psoriasis.
 Xu et al., 2017


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024