| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Malignant lymphoma | Lymphoma cell lines | Down | DKC1 | PI3K-Akt signaling pathway | miR-150 directly targets DKC1, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells. | Watanabe et al., 2011 |
| Malignant lymphoma | Lymphoma cell lines | Down | AKT | PI3K-Akt signaling pathway | miR-150 directly targets AKT2, reduces levels of phosphorylated AKT and increases levels of tumor suppressors such as Bim and p53. Downregulation of hsa-miR-150 induces continuous activation of the PI3K-PI3K-Akt signaling pathway, leading to telomerase activation and immortalization of cancer cells. | Watanabe et al., 2011 |
| T-cell acute lymphoblastic leukemia | MOLT-3, Jurkat, CCRF-HSB-2 | Up | NOTCH3 | Notch signaling pathway | Overexpression of miR-150 downregulates the expression of NOTCH3 and has adverse effects on proliferation and survival T-cell acute lymphoblastic leukemia. | Ghisi et al., 2011 |
| Ovarian cancer | SK-OV-3, SNU-119 | PI3K-Akt signaling pathway | Decreased expression of miRNA-150 enhances pertuzumab resistance in ovarian cancer cells through AKT activation. | Wuerkenbieke et al., 2015 | ||
| Ovarian cancer | SK-OV-3, SNU-119 | Down | PI3K-Akt signaling pathway | Decreased expression of miRNA-150 regulates the pertuzumab resistance in ovarian cancer through PI3K-Akt signaling pathway. | Wuerkenbieke et al., 2015 |