| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Chronic lymphocytic leukemia | Peripheral blood | Down | MCL1 | MCL1 pathway | p53 deletion results in a decrease of miR-16-1, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia. | Liu et al., 2014 |
| B-cell chronic lymphocytic leukemia | Peripheral blood | Down | TP53 | p53 signaling pathway | Over-expression of hsa-miR-16-1 suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis. | Fabbri et al, 2011 |
| Chronic lymphocytic leukemia | Peripheral blood | Down | BCL2 | Apoptosis pathway | miR-16-1 downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia. | Cimmino et al., 2005 |
| Non-small cell lung cancer | A-549 | TLR1 | NF-Kappa B signaling pathway | MicroRNA-16 increases radiation sensitivity through NF-Kappa B signaling pathway by targeting TLR1. | Lan et al., 2015 | |
| Non-small cell lung cancer | Lung | Down | BCL 2 | Caspase 3 pathway | Overexpression of miR-16 enhances paclitaxel induced apoptotic cell death by inhibiting anti-apoptotic protein Bcl-2. | Chatterjee et al., 2015 |
| Hepatocellular carcinoma | SK-HEP-1 | PI3K | PI3K-Akt signaling pathway | Upregulation of microRNA-16 suppresses PI3K expression and Akt phosphorylation. MicroRNA-16 overexpression inhibits the proliferation, invasion and metastasis of hepatocellular carcinoma cells, and these effects are associated with the PI3K-Akt signaling pathway. | Wu et al., 2015 |