| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Mantle cell lymphoma | Z-138, Granta-519, JeKo-1 | Up | PHLPP2 | PI3K-Akt signaling pathway | Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PHLPP2 and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma. | Rao et al., 2012 |
| Mantle cell lymphoma | Z-138, Granta-519, JeKo-1 | Up | PTEN | PI3K-Akt signaling pathway | Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting PTEN and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma. | Rao et al., 2012 |
| Mantle cell lymphoma | Z-138, Granta-519, JeKo-1 | Up | BIM | PI3K-Akt signaling pathway | Overexpression of miR-17-92 cluster activates the PI3K-Akt signaling pathway through targeting BIM and inhibites chemotherapy-induced apoptosis in mantle cell lymphoma. | Rao et al., 2012 |
| Chronic lymphocytic leukemia | Peripheral blood | Up | Toll-like receptor signaling pathway | miR-17-92 family regulates pro-survival and growth-promoting responses of chronic lymphocytic leukemia cells to TLR9 triggering. | Bomben et al., 2012 |