| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Non-Hodgkin lymphoma | SU-DHL-4, SU-DHL-10 | Up | BIM | Apoptosis pathway | Ectopic suppression of miR-181a inhibits cell adhesion dependent Bim down-regulation, resulting in cell apoptosis. hsa-miR-181a plays a significant role in the regulation of lymphoma survival and cell adhesion regulated drug resistance. | Lwin et al., 2010 |
| T-cell leukemia | T-leukemia cell line | Up | PI3K-Akt signaling pathway | miR-181a involves in acquired chemoresistance in T-cell leukemia. miR181a acts as a biomarker of T-cell leukemia via modulation of PI3K-Akt signaling pathway. | Yan et al., 2015 | |
| T-cell lymphoma | T-lymphoma cell line | Up | PI3K-Akt signaling pathway | miR-181a involves in acquired chemoresistance in T-cell lymphoma. miR181a acts as a biomarker of T-cell lymphoma via modulation of PI3K-Akt signaling pathway. | Yan et al., 2015 | |
| Acute myeloid leukemia | KG-1a, MV4-11, HL-60, HEK293T | Up | KRAS | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating KRAS and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| Acute myeloid leukemia | KG-1a, MV4-11, HL-60, HEK293T | Up | NRAS | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating NRAS and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| Acute myeloid leukemia | KG-1a, MV4-11, HL-60, HEK293T | Up | MAPK1 | RAS signaling pathway | hsa-miR-181a targets RAS signaling pathway through downregulating MAPK1 and decreases acute myeloid leukemia growth. | Huang et al., 2016 |
| Cervical cancer | End1/E6E7 | Up | PI3K-Akt signaling pathway | MicroRNA-181a functions as an oncogene in cervical cancer. Reduced expression of miR-181a is associated with enhanced expression of PTEN and decreased phosphorylation of Akt and FOXO1. | Xu et al., 2016 |