Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Hepatitis C virus infection | Hep-G2 | SREBP2 | SREBP pathway | Upregulation of microRNA-185 suppresses the expression of SREBP2 by HCV core protein. | Li et al., 2015 | |
Gastric cancer | MGC-803, BGC-823, GES-1 | Down | TRIM29 | Wnt signaling pathway | Upregulation of miR-185 suppresses TRIM29 expression and activity of Wnt signaling pathway in gastric cancer. | Qiu et al., 2015 |
Esophageal squamous cell carcinoma | Eca-109 | Up | RAGE | RAGE pathway | Upregulation of miR-185 inhibits migration and invasion and reduces the capacity to develop distal pulmonary metastases via the RAGE pathway. | Jing et al., 2015 |
Hepatocellular carcinoma | Hepatocyte | Down | DNMT1 | PI3K-Akt signaling pathway | hsa-miR-185 acts as a tumor suppressor microRNA that prevents hepatocellular carcinoma cell growth by downregulating DNMT1, leading to PTEN induction and Akt inhibition. | Qadir et al., 2014 |
Nasopharyngeal carcinoma | CNE-2 | Down | WNT2B | Wnt signaling pathway | MicroRNA-185 controls the radioresistance of nasopharyngeal carcinoma through targeting WNT2B expression. | Li et al., 2014 |