| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | MGC-803, HGC-27 | Down | HIF 1 ALPHA | Apoptosis pathway | MicroRNA-18a induces gastric cancer cell apoptosis through the HIF-1-alpha/mitochondrial apoptosis pathway. | Wu et al., 2015 |
| Gastric cancer | Stomach | Up | IRF2 | p53 signaling pathway | MicroRNA-18a regulates the expression of P53 by directly targeting IRF2 in gastric cancer. | Chen et al., 2016 |
| Gastric cancer | SGC-7901 | Up | S6K1 | mTOR pathway | Overexpression of miR-18a decreases the phosphorylation of S6K1 and inactivates the mTOR pathway. | Zheng et al., 2013 |
| Gastric cancer | SGC-7901 | Up | 4E BPl | mTOR pathway | Upregulation of miR-18a decreases the phosphorylation of 4E-BPI and inactivates the mTOR pathway. | Zheng et al., 2013 |
| Gastric cancer | Stomach | Up | IRF2 | p53 signaling pathway | Overexpression of hsa-miR-18a downregulates the expression of IRF2. Mir-18a modulates p53 expression by targeting IRF2 and regulates p53 signaling in gastric cancer. | Chen et al., 2016 |