| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatitis C virus infection | Huh-7.5.1 | Up | PI3K-Akt signaling pathway | MicroRNA-199a promotes HCV replication by regulating PI3K-Akt signaling pathway. | Wang et al., 2015 | |
| Hepatitis C virus infection | Huh-7.5.1 | Up | RAS signaling pathway | MicroRNA-199a promotes HCV replication by regulating Ras/ERK pathway. | Wang et al., 2015 | |
| Hepatitis C virus infection | Huh-7.5.1 | Up | Wnt signaling pathway | MicroRNA-199a promotes HCV replication by regulating Wnt signaling pathway. | Wang et al., 2015 | |
| Gastric cancer | GC9811, GC9811-P, MKN28, GES-1 | Up | E CADHERIN | Cadherin signaling pathway | Suppression of miR-199a impairs the metastatic potential of gastric cancer cells. Upregulation of miR-199a-5p inhibits the expression of E-cadherin. | Zhao et al., 2014 |
| Gastric cancer | Stomach | Down | MTOR | mTOR pathway | Overexpression of miRNA-199a inhibits cancer cell proliferation through targeting the mTOR signaling pathway. | Peng et al., 2014 |
| Gastric cancer | SNU-16 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-199a suppresses the ability of TGF-beta to induce gastric cancer cell growth arrest and apoptosis through targeting Smad4. | Zhang et al., 2012 |
| Non-alcoholic fatty liver disease | Hep-G2 | Up | CAV1 | PPAR signaling pathway | Overexpression of miR199a in hepatocytes is associated with impaired FA beta-oxidation in mitochondria and aberrant lipid deposits through the PPAR signaling pathway. | Li et al., 2014 |
| Breast cancer | Breast | Down | PAK4 | ERK pathway | MicroRNA-199a inhibits migration and invasion of breast cancer cells by inactivating PAK4/MEK/ERK signaling pathway. | Li et al., 2015 |