| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Stomach | Up | PI3K-Akt signaling pathway | Upregulation of miR-19a induces the epithelial-mesenchymal transition through activating the PI3K-Akt signaling pathway. | Lu et al., 2015 | |
| Gastric cancer | SGC-7901, NUGC-3 | Up | PI3K-Akt signaling pathway | Upregulation of miR-19a increases the epithelial-mesenchymal transition via activating PI3K-Akt signaling pathway. | Lu et al., 2014 | |
| Breast cancer | MCF-7, MCF-10A, MDA-MB-468, HCT 116, PANC-1 | BRCA2 | Homologous recombination DNA repair pathway | Upregulation of hsa-miR-19a is associated with reduced expression of BRCA2 in breast cancer. | Mogilyansky et al., 2016 | |
| Laryngeal squamous cell carcinoma | HEp-2 | Up | TIMP2 | TIMP-2 pathway | MicroRNA-19a functions as an oncogene in the progression of laryngeal squamous cell carcinoma by targeting TIMP-2 expression. | Wu etal., 2013 |
| Asthma | Bronchial epithelial cell | Up | TGFBR2 | TGF-beta signaling pathway | hsa-miR-19a increased bronchial epithelial cell proliferation in severe asthma through inhibiting TGF-beta receptor 2 mRNA level. | Haj-salem et al., 2015 |