| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Stomach | CREB1 | CREB signaling pathway | Upregulation of CREB1 is associated with lymph node metastasis, distant metastasis and tumor stage and poor outcome in gastric cancer. MicroRNA-200b directly targets and inhibits the expression of CREB1. | Wang et al., 2015 | |
| Gastric cancer | Stomach | Down | WNT1 | Wnt signaling pathway | MicroRNA-200b suppresses gastric cancer growth and increases the antitumor effect of Diallyl disulfide through Wnt signaling pathway. | Tang et al., 2013 |
| Chondrosarcoma | JJ012 | Down | VEGF A | PI3K-Akt signaling pathway | CCL5 enhances VEGF-dependent angiogenesis by suppressing miR-200b via PI3K-Akt signaling pathway in human chondrosarcoma cells. | Liu et al., 2014 |
| Hepatocellular carcinoma | BEL-7402, SMMC-7221 | Down | RHOA | RhoA pathway | Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting RhoA. | Wong et al., 2015 |
| Hepatocellular carcinoma | BEL-7402, SMMC-7221 | Down | ROCK2 | RhoA pathway | Over-expression of miR-200b significantly inhibits lung metastasis in hepatocellular carcinoma cells through targeting ROCK2. | Wong et al., 2015 |
| Breast cancer | Breast | Down | NF KAPPA B | NF-Kappa B signaling pathway | MicroRNA-200b inhibits breast cancer cell growth and migration, and NF-Kappa B activation in breast cancer. | Wu et al., 2016 |
| Triple negative breast cancer | MCF-7, MDA-MB-231, MDA-MB-157 | RhoGDI pathway | MicroRNA-200b inhibits the RhoGDI pathway, which leads to non-canonical suppression of epithelial-to-mesenchymal transition in triple-negative breast cancer. | Rhodes et al., 2015 | ||
| Triple negative breast cancer | MCF-7, MDA-MB-231, MDA-MB-157 | RhoGDI pathway | MicroRNA-200b inhibits the RhoGDI pathway, which leads to non-canonical suppression of epithelial-to-mesenchymal transition in triple-negative breast cancer. | Rhodes et al., 2015 | ||
| Hepatocellular carcinoma | Hepatocyte | Down | RHOA | RhoA pathway | RhoA is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway. | Wong et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | ROCK2 | RhoA pathway | ROCK2 is the downstream target of hsa-miR-200b. Re-expression of hsa-miR-200b suppresses lung metastasis through downregulating RhoA pathway. | Wong et al., 2015 |