| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Cutaneous T-cell lymphoma | HuT 78, MyLa | Down | JAGGED1 | Notch signaling pathway | Overexpression of miR-200c suppresses the expression of Jagged1, associated with reduction of Notch1 levels in cutaneous T-cell lymphomas. | Gallardo et al., 2015 |
| Hepatitis C virus infection | Hepatocyte | Up | FAP1 | Src pathway | Upregulation of miR-200c down-regulates the expression of FAP1, a critical regulator of Src pathway that play an important role in the development of fibrosis and production of fibrogenic growth factors. | Ramachandran et al., 2014 |
| Lung cancer | A-549 | Down | Cadherin signaling pathway | Upregulation of miR-200c suppresses cell migration and invasion with reducing the expression of EZH2 and enhancing the expression of E-cad. | Shan et al., 2016 | |
| Prostate cancer | DU145, PC-3 | Down | IRS1 | IRS1 signaling pathway | MicroRNA-200c inhibits prostate cancer cell growth by suppressing IRS1 expression. | Su et al., 2015 |