Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Gastric cancer | SGC-7901, MGC-803, HGC-27, BGC-823 | Down | PIK3CA | PI3K-Akt signaling pathway | MicroRNA-203 suppresses cell proliferation and invasion in gastric cancer cells through directly inhibiting the PIK3CA expression. | Liang et al., 2015 |
Lung cancer | Lung | Up | FZD2 | Wnt signaling pathway | MicroRNA-203 directly inhibits cancer metastasis through Wnt signaling pathway by targeting FZD2. | Mine et al., 2015 |
Lung cancer | A-549, H1975, HCC827 | SRC | ERK pathway | MicroRNA-203 inhibits the proliferation and migration and enhances the apoptosis of lung cancer cells by down-regulating the expression of SRC. | Wang et al., 2014 | |
Ovarian cancer | IOSE-80, IOSE-144, OVCA429, OVCA433 | Up | PDHB | Glycolysis pathway | MicroRNA-203 functions as an ocogene in ovarian cancer by inducing glycolysis. | Xiaohong et al., 2016 |