Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Gastric cancer | Stomach | Down | SIRT1 | SIRT1 pathway | Down-regulation of miR-204 is associated with gastric cancer cell invasion via regulation of the SIRT1-LKB1 pathway. | Zhang et al., 2013 |
Breast cancer | Breast | Down | SAM68 | Wnt signaling pathway | MicroRNA-204 suppresses the self-renewal of breast cancer cells by inhibiting Sam68 through regulating the Wnt signaling pathway. | Wang et al., 2015 |
Breast cancer | Breast | Down | JAK2 | Jak-STAT signaling pathway | MicroRNA-204 suppresses JAK2 expression, which further inhibits the activation of STAT3, BCl-2 and survivin in breast cancer. | Wang et al., 2015 |