microRNA Name:

hsa-miR-20a

Gene Score: 0.0152

Pathway Score: 0.041

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Primary CNS lymphoma Lymph node Up Myc pathway Overexpression of hsa-miR-20a activates Myc pathway in primary CNS lymphomas.
Fischer et al., 2011
Gastric cancer Gastric cancer tissue Up CYLD NF-Kappa B signaling pathway MicroRNA-20a directly suppresses the expression of CYLD, leads to activation of the NF-Kappa B signaling pathway and the downstream targets, livin and survivin, which potentially induces gastric cancer chemoresistance.
Zhu et al., 2016
Gastric cancer BGC-823, HGC-27 Up FBXO31 CDK pathway FBXO31 promotes G1 phase cell cycle arrest and causes the growth inhibitory role of gastric cancer. The upregulation of miR-20a is associated with suppression of FBXO31 in gastric cancer tissues.
Zhang et al., 2014
Gastric cancer Stomach Up EGR2 EGR2 signaling pathway MicroRNA-20a enhances the growth, migration and invasion of gastric cancer cells, promotes the chemoresistance of gastric cancer cells to cisplatin by targeting early growth response 2.
Li et al., 2013
Hepatocellular carcinoma Hepatocyte Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-20a downregulates PTEN expression. Mir-20a promotes HCC cell radioresistance by activating the PTEN/PI3K-Akt signaling pathway.
Zhang et al., 2015