Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Primary CNS lymphoma | Lymph node | Up | Myc pathway | Overexpression of hsa-miR-20a activates Myc pathway in primary CNS lymphomas. | Fischer et al., 2011 | |
Gastric cancer | Gastric cancer tissue | Up | CYLD | NF-Kappa B signaling pathway | MicroRNA-20a directly suppresses the expression of CYLD, leads to activation of the NF-Kappa B signaling pathway and the downstream targets, livin and survivin, which potentially induces gastric cancer chemoresistance. | Zhu et al., 2016 |
Gastric cancer | BGC-823, HGC-27 | Up | FBXO31 | CDK pathway | FBXO31 promotes G1 phase cell cycle arrest and causes the growth inhibitory role of gastric cancer. The upregulation of miR-20a is associated with suppression of FBXO31 in gastric cancer tissues. | Zhang et al., 2014 |
Gastric cancer | Stomach | Up | EGR2 | EGR2 signaling pathway | MicroRNA-20a enhances the growth, migration and invasion of gastric cancer cells, promotes the chemoresistance of gastric cancer cells to cisplatin by targeting early growth response 2. | Li et al., 2013 |
Hepatocellular carcinoma | Hepatocyte | Up | PTEN | PI3K-Akt signaling pathway | Overexpression of hsa-miR-20a downregulates PTEN expression. Mir-20a promotes HCC cell radioresistance by activating the PTEN/PI3K-Akt signaling pathway. | Zhang et al., 2015 |