| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Primary CNS lymphoma | Lymph node | Up | Myc pathway | Overexpression of hsa-miR-20b activates Myc pathway in primary CNS lymphomas. | Fischer et al., 2011 | |
| Papillary thyroid carcinoma | K1, TPC-1 | Down | SOS1 | MAPK signaling pathway | MicroRNA-20b regulates papillary thyroid carcinoma initiation, progression, and metastasis through targeting son of sevenless homolog 1 (SOS1). | Hong et al., 2016 |
| Papillary thyroid carcinoma | K1, TPC-1 | Down | ERK2 | MAPK signaling pathway | MicroRNA-20b suppresses the activity of the MAPK signaling pathway by targeting extracellular signal-regulated kinase 2 (ERK2). MiR-20b plays an important role in initiation, progression, and metastasis of papillary thyroid carcinoma. | Hong et al., 2016 |
| Osteosarcoma | MG-63, U2OS | Down | HIF 1 ALPHA | VEGF signaling pathway | MicroRNA-20b inhibits cell invasion and proliferation by down-regulating the expression of HIF-1-alpha. | Liu et al., 2016 |