microRNA Name:

hsa-miR-21

Gene Score: 0.0823

Pathway Score: 0.2213

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up FOXO1 FoxO signaling pathway miR-21 plays an important oncogenic role by down regulating the expression of FOXO1 and modulating the FOXO1 pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PTEN PI3K-Akt signaling pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the PI3K-Akt signaling pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Diffuse Large B-cell lymphoma OCI-Ly1, OCI-Ly18, SU-DHL-7 Up PTEN mTOR pathway miR-21 plays an important oncogenic role by down regulating the expression of PTEN and modulating the mTOR pathway in Diffuse Large B-cell lymphoma.
 Go et al., 2015
Sezary syndrome HuT 78, H9, HH Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-21 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival.
 Cristofoletti et al., 2013
Diffuse Large B-cell lymphoma CRL2631 Up PTEN PI3K-Akt signaling pathway hsa-miR-21 regulates the PI3K-Akt signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen.
 Bai et al., 2013
Alzheimer's disease Cerebral cortex Down PTEN PI3K-Akt signaling pathway MicroRNA-212 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Alzheimer's disease Cerebral cortex Down FOXO3A FoxO signaling pathway MicroRNA-212 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway.
 Wong et al., 2013
Multiple sclerosis COS-7 Up SMAD4 TGF-beta signaling pathway Over-expression of miR-212 suppresses the expression of SMAD4. MicroRNA-212 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Hepatitis C virus infection HEK293 Up MYD88 IFN signaling pathway MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting MyD88.
 Chen et al., 2014
Hepatitis C virus infection HEK293 Up IRAK1 IFN signaling pathway MicroRNA-21 is over-expressed during HCV infection and down-regulates IFN signaling pathway via targeting IRAK1.
 Chen et al., 2014
Chronic hepatitis C virus infection Huh-7.5 Up SMAD7 TGF-beta signaling pathway MicroRNA-21 down-regulates the expression of SMAD7 and enhances TGF-beta signaling, leads to increase fibrogenesis.
 Marquez et al., 2010
Gastric cancer Gastric cancer tissue Up PTEN PI3K-Akt signaling pathway MicroRNA-21 enhances the phosphorylation of Akt through dropping PTEN which promotes the epithelial-mesenchymal transition in gastric cancer induced by TGF-beta 1.
 Liet al., 2016
Hepatocellular carcinoma Stomach Down RBP2 CDK pathway Upregulation of hsa-miR-212 down-regulates the expression of RBP2 and suppresses cell proliferation in hepatocellular carcinoma.
 Liang et al., 2013
Gastric cancer SGC-7901 Up PTEN PI3K-Akt signaling pathway hsa-miR-21 promotes cell survival and cisplatin resistance in gastric cancer through inhibiting phosphatase and tension homolog deleted on chromosome 10 (PTEN) expression level and activation of PI3K-Akt signaling pathway.
 Yang et al., 2013
Gastric cancer MKN-45, SGC-7901 Down ROBO1 Slit/Robo pathway Overexpression of miR-218 inhibits Robo1 expression and isuppresses tumor cell invasion and metastasis in gastric cancer.
 Tie et al., 2010
Hepatocellular carcinoma Hep-G2 Up HBP1 p53 signaling pathway MicroRNA-21 induces hepatocellular carcinoma progression through targeting Hbp1-p53-Srebp1c pathway.
 Wu et al., 2015
Non-alcoholic fatty liver disease Hep-G2 Up HBP1 p53 signaling pathway MicroRNA-21 induces hepatic lipid accumulation through targeting Hbp1-p53-Srebp1c pathway.
 Wu et al., 2015
Lung cancer A-549,NCI-H1650 Up CTNNBIP1 Wnt signaling pathway MicroRNA-214 plays an important role in cancer stem-like cells self-renewal and stemness by down-regulating the expression of CTNNBIP1 in lung adenocarcinoma.
 Qi et al., 2015
Non-small cell lung cancer Lung Up PTEN NF-Kappa B signaling pathway Suppression of NF-Kappa B signaling pathway enhances cisplatin sensitivity in non-small cell lung cancer.
 Yang et al., 2015
Lung cancer A-549 Up PI3K-Akt signaling pathway Inhibition of miR-21 reverses lung cancer cell multi drug resistance through inhibition of the Akt signaling pathway.
 Dong et al., 2015
Breast cancer Breast Up PTEN PI3K-Akt signaling pathway MicroRNA-214 functions as oncogene in breast cancer by inhibiting the PI3K-Akt signaling pathway.
 Wang et al., 2016
Breast cancer MCF-7 PTEN PI3K-Akt signaling pathway MiR-21 regulates autophagy and apoptosis by suppression phosphatase and tensin homolog (PTEN) through targeting PI3K-Akt signaling pathway.
 Yu et al., 2016
Breast cancer 4T1 Up PTEN PI3K-Akt signaling pathway MicroRNA-21 functions as a fine tuner in the regulation of PI3K-Akt signaling pathway in the expansion of CCR6(+) Tregs in tumor sites.
 Hu et al., 2015
Hepatocellular carcinoma Hepatocyte Up PTEN PI3K-Akt signaling pathway Overexpression of hsa-miR-21 reduces PTEN expression and sequential Akt activation. It suppresses autophagy through PI3K-Akt signaling pathway.
 He et al., 2015
Non-alcoholic fatty liver disease Hep-G2 Up HBP1 p53 signaling pathway Downregulation of hsa-miR-21 increases expression of HBP1 and p53 and decreased lipogenesis. miR-21 stimulates hepatic lipid accumulation and cancer development through modulation of Hbp1-p53-Srebp1c pathway.
 Wu et al., 2015
Hepatocellular carcinoma Hepatocyte Down IGF2BP2 IGF signaling pathway Overexpression of hsa-miR-216b suppresses HCC cell proliferation and invasion by targeting IGF2BP2 through HBx-miR-216b-IGF2BP2 signaling pathway.
 Liu et al., 2015
Hepatocellular carcinoma Hepatocyte Down HOXA10 PI3K-Akt signaling pathway Overexpression of miR-218 reduces cancer cell proliferation in hepatocellular carcinoma through PI3K-Akt signaling pathway with possible association of HoxA10.
 Xiao et al., 2014
Hepatocellular carcinoma Hepatocyte Up MAP2K3 MAPK signaling pathway Overexpression of miR-21 post-transcriptionally inhibits MAP2K3 signaling in hepatocellular carcinoma cell development.
 Xu et al., 2013
Cervical cancer HeLa, SiHa Up PI3K-Akt signaling pathway MicroRNA-21 confers reduced autophagy in cervical cancer cells through the PI3K-Akt signaling pathway.
 Song et al., 2016
Cervical cancer HeLa, Ca Ski Up PTEN PTEN pathway MicroRNA-21 induces proliferation, migration and invasion in cervical cancer cells through targeting the PTEN expression.
 Xu et al., 2015
Renal cell carcinoma A-498, 786-O CAV2 Focal adhesion pathway MicroRNA-218 suppresses cell migration and invasion in renal cell carcinoma by inhibiting caveolin-2 expression.
 Yamasaki et al., 2013
Medullary thyroid carcinoma Thyroid gland Up PDCD4 PDCD4 pathway MicroRNA-21 regulates the expression of PDCD4 in medullary thyroid carcinoma.
 Pennelli et al., 2015
Osteosarcoma MG-63 Up PTEN PI3K-Akt signaling pathway MicroRNA-21 plays an active role in osteosarcoma through PI3K-Akt signaling pathway by inhibiting PTEN expression.
 Lv et al., 2016
Pancreatic carcinoma PANC-1 Down JAK2 Jak-STAT signaling pathway MicroRNA-216a acts as a tumor suppressor in pancreatic cancer cells by inhibiting the Jak-STAT signaling pathway.
 Hou et al., 2015
Asthma Airway smooth muscle Up PTEN PI3K-Akt signaling pathway MicroRNA-21 enhanced proliferation and migration of human airway smooth muscle (HASM) cell in asthma through activation of phosphoinositide 3 kinase pathway.
 Liu et al., 2015
Atherosclerosis Peripheral blood mononuclear cells Up TGFBR TGF-beta signaling pathway Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis.
 Li et al., 2015
Atherosclerosis Peripheral blood mononuclear cells Up SMAD7 TGF-beta signaling pathway Overexpression of miR-21 downregulates the frequency of circulating Treg cells through TGF-beta signaling pathway in atherosclerosis.
 Li et al., 2015
Chronic pancreatitis PANC-1, BxPC-3 Down SIRT1 SIRT1 pathway Expression of miR-217 is significantly decreased in chronic pancreatitis cell and its expression is negatively correlated with SIRT1 expression.
 Deng et al., 2014
Alcoholic liver disease Hepatic stellate cells Up FAS Apoptosis pathway Downregulation of miR-21 increased the expression of FASL in alcoholic liver injury.
 Francis et al., 2014


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024