| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Alzheimer's disease | Cerebral cortex | Down | PTEN | PI3K-Akt signaling pathway | MicroRNA-212 regulates cell survival by direct suppression of PTEN, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| Alzheimer's disease | Cerebral cortex | Down | FOXO3A | FoxO signaling pathway | MicroRNA-212 regulates cell survival by direct suppression of FOXO3a, which is the key elements of AKT signaling pathway. | Wong et al., 2013 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Over-expression of miR-212 suppresses the expression of SMAD4. MicroRNA-212 targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Hepatocellular carcinoma | Stomach | Down | RBP2 | CDK pathway | Upregulation of hsa-miR-212 down-regulates the expression of RBP2 and suppresses cell proliferation in hepatocellular carcinoma. | Liang et al., 2013 |