| Chronic lymphocytic leukemia |
Peripheral blood |
Up |
PTEN |
PI3K-Akt signaling pathway |
Up-regulation of microRNA-22 is associated with suppression of phosphatase and tensin homolog (PTEN) and phosphoinositide 3-kinase (PI3K)/PI3K-Akt signaling pathway activation in chronic lymphocytic leukemia. |
Palacios et al., 2015 |
| Hepatitis C virus infection |
Huh-7.5.1 |
Up |
SOCS1 |
Jak-STAT signaling pathway |
MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS1. |
Xu et al., 2014 |
| Hepatitis C virus infection |
Huh-7.5.1 |
Up |
SOCS3 |
Jak-STAT signaling pathway |
MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS3. |
Xu et al., 2014 |
| Gastric cancer |
Gastric cancer tissue |
Up |
MTOR |
mTOR pathway |
MicroRNA-224 down-regulates the expression of mTOR, leads to the activation of cell proliferation in gastric cancer. |
Zhang et al., 2016 |
| Gastric cancer |
Stomach |
Up |
FBXW7 |
FBXW7 pathway |
MiR-223 enhances the cisplatin resistance of human gastric cancer cells through regulating cell cycle by down-regulating FBXW7. |
Zhou et al., 2015 |
| Gastric cancer |
MKN45, NUGC-3, NUGC-4, KATO III |
|
FBXW7 |
FBXW7 pathway |
MicroRNA-223/FBXW7 pathway regulates the sensitivity of a HER2-positive gastric cancer cell line to trastuzumab via the modulation of apoptosis. |
Eto et al., 2015 |
| Gastric cancer |
Stomach |
Down |
WNT1 |
Wnt signaling pathway |
MicroRNA-22 suppresses gastric cancer growth and increases the antitumor effect of Diallyl disulfide through Wnt signaling pathway. |
Tang et al., 2013 |
| Epithelial-mesenchymal transition |
A-549, HBE |
Down |
HMGA2 |
TGF-beta signaling pathway |
Upregulation of miR?221 down-regulates HMGA2 to suppress BLM?induced pulmonary fibrosis through the TGF?beta1/Smad3 signaling pathway. |
Wang et al., 2016 |
| Non-small cell lung cancer |
PC-9 |
|
IGF 1R |
IGF signaling pathway |
MicroRNA-223 increases the acquired resistance of non-small cell lung cancer cells to erlotinib through inhibition of the IGF-1R/Akt/S6 signaling pathway. |
Zhao et al., 2016 |
| Non-small cell lung cancer |
HCC827 |
Up |
|
PI3K-Akt signaling pathway |
Decreased expression of miR-223 is associated with resistance of non-small cell lung cancer cells to erlotinib through the activation of the IGF1R/phosphatidylinositol 3-kinase (PI3K)/PI3K-Akt signaling pathway. |
Han et al., 2016 |
| Non-small cell lung cancer |
Lung |
Up |
CASPASE 3 |
NF-Kappa B signaling pathway |
MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP3. |
Cui et al., 2015 |
| Non-small cell lung cancer |
Lung |
Up |
CASPASE 7 |
NF-Kappa B signaling pathway |
MicroRNA-224 plays an important role in the lung cancer pathogenesis through down-regulating the expression of CASP7. |
Cui et al., 2015 |
| Malignant pleural mesothelioma |
JU77, LO68, NO36 |
Down |
STMN1 |
JNK signaling pathway |
MicroRNA-223 regulates malignant pleural mesothelioma cell motility via JNK signaling pathway. |
Birnie et al., 2015 |
| Triple negative breast cancer |
MCF-7, MDA-MB-231, MDA-MB-435, SK-BR-3 |
Down |
HAX1 |
Mitochondria/ROS pathway |
MicroRNA-223 enhances the sensitivity of triple-negative breast cancer to TRAIL-induced apoptosis by down-regulating the expression of HAX-1. |
Sun et al., 2016 |
| Breast cancer |
MCF-7, MDA-MB-231, MCF-10A |
Up |
TIP60 |
EMT pathway |
Blocking endogenous miR-22 enhances TIP60 levels, which in turn suppresses the migration and invasion capacity of metastatic breast cancer. |
Pandey et al., 2015 |
| Hepatocellular carcinoma |
Hepatocyte |
Up |
|
PI3K-Akt signaling pathway |
hsa-miR-222 affects cell proliferation, migration and invasion, and enhance the resistance of hepatocellular carcinoma cells to sorafenib via regulation of the PI3K-Akt signaling pathway. |
Liu et al., 2014 |
| Cervical cancer |
HeLa, SiHa |
Up |
PTEN |
PI3K-Akt signaling pathway |
MicroRNA-221 decreases the sensitivity of cervical cancer cells to gefitinib via the PI3K-Akt signaling pathway. |
Du et al., 2016 |
| Ovarian cancer |
HO-8910, HO8910PM |
Up |
KLLN |
KLLN-cyclin A pathway |
Overexpression of microRNA-224 induces proliferation of ovarian cancer cells by down-regulating KLLN expression. |
Hu et al., 2016 |
| Laryngeal squamous cell carcinoma |
HEp-2 |
Up |
APAF 1 |
Apoptosis pathway |
MicroRNA-221 enhances the proliferation of laryngeal cancer cells by down-regulating Apaf-1 expression. |
Sun et al., 2015 |
| Atherosclerosis |
HUVEC |
|
PTEN |
PTEN pathway |
MiR-221 from human aortic smooth muscle cell-derived exosomes inhibits autophagy in HUVECs by modulating PTEN signaling pathway. |
Li et al., 2016 |
| Atherosclerosis |
HUVEC |
|
PTEN |
PTEN pathway |
MiR-221 from human aortic smooth muscle cell-derived exosomes inhibits autophagy in HUVECs by modulating PTEN signaling pathway. |
Li et al.,2016 |