| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatitis C virus infection | Huh-7.5.1 | Up | SOCS1 | Jak-STAT signaling pathway | MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS1. | Xu et al., 2014 |
| Hepatitis C virus infection | Huh-7.5.1 | Up | SOCS3 | Jak-STAT signaling pathway | MicroRNA-221 accentuates IFN's anti-HCV effect by suppressing SOCS3. | Xu et al., 2014 |
| Epithelial-mesenchymal transition | A-549, HBE | Down | HMGA2 | TGF-beta signaling pathway | Upregulation of miR?221 down-regulates HMGA2 to suppress BLM?induced pulmonary fibrosis through the TGF?beta1/Smad3 signaling pathway. | Wang et al., 2016 |
| Cervical cancer | HeLa, SiHa | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-221 decreases the sensitivity of cervical cancer cells to gefitinib via the PI3K-Akt signaling pathway. | Du et al., 2016 |
| Laryngeal squamous cell carcinoma | HEp-2 | Up | APAF 1 | Apoptosis pathway | MicroRNA-221 enhances the proliferation of laryngeal cancer cells by down-regulating Apaf-1 expression. | Sun et al., 2015 |
| Atherosclerosis | HUVEC | PTEN | PTEN pathway | MiR-221 from human aortic smooth muscle cell-derived exosomes inhibits autophagy in HUVECs by modulating PTEN signaling pathway. | Li et al., 2016 |