| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Osteosarcoma | Zos | Down | JAGGED1 | Notch signaling pathway | Upregulation of miR-26a inhibits the expression of Jagged1, one of the Notch ligand. MicroRNA-26a functions as tumor suppressor via suppression of Jagged1/Notch signaling. | Lu et al., 2016 |
| Non-small cell lung cancer | Lung | HMGA2 | PI3K-Akt signaling pathway | Down-regulation of miR-26a plays an important role in the mechanism of cisplatin resistance in human non-small cell lung cancer via HMGA2-mediated E2F1-PI3K-Akt signaling pathway. | Yang et al., 2016 | |
| Hepatocellular carcinoma | Hepatocyte | M CSF | PI3K-Akt signaling pathway | hsa-miR-26a downregulates M-CSF expression and inhibits macrophage recruitment via PI3K-Akt signaling pathway. | Chai et al., 2015 | |
| Hepatocellular carcinoma | Hepatocyte | Down | HGF | c-MET signaling pathway | hsa-miR-26a inhibits tumor angiogenesis in hepatocellular carcinoma via HGF-cMet signaling pathway. | Yang et al., 2014 |
| Hepatocellular carcinoma | Hepatocyte | PIK3C2 ALPHA | PI3K-Akt signaling pathway | MicroRNA-26a regulates angiogenesis of hepatocellular carcinoma through the PIK3C2-alpha/Akt/HIF-1-alpha/VEGFA pathway. | Chai et al., 2014 | |
| Osteosarcoma | Bone | Down | JAGGED1 | Notch signaling pathway | MicroRNA-26a suppresses stem cell-like phenotype and tumor growth of osteosarcoma by down-regulating Jagged1 expression. | Lu et al., 2016 |
| Osteosarcoma | MG-63, U2OS | Up | GSK 3 BETA | Wnt signaling pathway | MicroRNA-26a plays an important role in the proliferation of human osteosarcoma cells through regulating Wnt signaling pathway. | Qu et al., 2016 |