| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | Gastric cancer tissue | Down | KPNA2 | JNK signaling pathway | MicroRNA-26b suppresses tumor metastasis by inhibiting the JNK signaling pathway in human gastric cancer. | Tsai et al., 2016 |
| Non-small cell lung cancer | Lung | Down | MIEN1 | NF-Kappa B signaling pathway | MicroRNA-26b inhibits non-small cell lung cancer metastasis by suppressing MIEN1 through NF-Kappa B signaling pathways. | Li et al., 2016 |
| Breast cancer | MCF-7 | Down | REL A | NF-Kappa B signaling pathway | MicroRNA-26b plays an important role in wound healing and tumor-induced endothelial cell tube formation by down-regulating NF-Kappa B expression. | Anbalagan et al., 2014 |
| Hepatocellular carcinoma | Hepatocyte | Down | MCL1 | MCL1 pathway | hsa-miR-26b directly targets Mcl-1 mRNA which plays an important role in the sensitization effect of miR-26b on TRAIL-induced apoptosis in HCC. miR-26b/Mcl-1 pathway might act as a sensitizer for chemotherapy. | Jiang et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | Down | USP9X | TGF-beta signaling pathway | Overexpression of miR-26b downregulates the expression of USP9X, which in turn affects epithelial-mesenchymal transition of hepatocellular carcinoma cells through TGF-beta signaling pathway. | Shen et al., 2014 |
| Hepatocellular carcinoma | Hepatocyte | TAK1 | NF-Kappa B signaling pathway | Overexpression of miR-26b inhibits NF-kappa B signaling pathway and thereby sensitized hepatocellular carcinoma cells to the doxorubicin-induced apoptosis by downregulating the expression of TAK1. | Zhou et al., 2014 | |
| Hepatocellular carcinoma | Hepatocyte | TAB3 | NF-Kappa B signaling pathway | Overexpression of miR-26b inhibits NF-kappa B signaling pathway and thereby sensitized hepatocellular carcinoma cells to the doxorubicin-induced apoptosis by downregulating the expression of TAB3. | Zhou et al., 2014 | |
| Prostate cancer | LNCaP, DU145, PC-3 | Down | ULK2 | Autophagy pathway | MicroRNA-26b suppresses autophagy in prostate cancer cells by down-regulating ULK2 expression. | Clotaire et al., 2016 |