| Acute myeloid leukemia |
SKM-1 |
Down |
ABCB1 |
NF-Kappa B signaling pathway |
Downregulation of miRNA-27a is associated with upregulation of ABCB1 expression and this effect is linked with a switch between the canonical and non-canonical NF-kappaB pathways. |
Messingerova et al., 2016 |
| Multiple sclerosis |
COS-7 |
Up |
TGFBR1 |
TGF-beta signaling pathway |
Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Multiple sclerosis |
COS-7 |
Up |
SMAD4 |
TGF-beta signaling pathway |
Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Multiple sclerosis |
COS-7 |
Up |
SMAD4 |
TGF-beta signaling pathway |
Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. |
Severin et al., 2016 |
| Hepatitis C virus infection |
Monocyte |
Up |
SPROUTY2 |
ERK pathway |
MicroRNA-27a regulates ERK phosphorylation by suppressing the expression of ERK inhibitor sprouty2 in monocytes. |
Saha et al., 2015 |
| Gastric cancer |
MGC-803, AGS, BGC-823, HGC-27, SGC-7901 |
Up |
BTG2 |
RAS signaling pathway |
Upregulation of miR-27a increases gastric cancer cell proliferation through targeting BTG2. |
Zhou et al., 2016 |
| Gastric cancer |
Gastric cancer tissue |
|
FZD7 |
Wnt signaling pathway |
Upregulation of miR-27b suppresses H. pylori infection-induced cell proliferation and WNT signaling pathway activation in gastric cancer cells. |
Geng et al., 2016 |
| Gastric cancer |
MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 |
Down |
ROR1 |
Jak-STAT signaling pathway |
MicroRNA-27b acts as a tumor-suppressor through the inhibition of oncogene ROR1 expression in gastric cancer. |
Tao et al., 2015 |
| Gastric cancer |
Stomach |
|
CREB1 |
CREB signaling pathway |
Upregulation of CREB1 is associated with lymph node metastasis, distant metastasis and tumor stage and poor outcome in gastric cancer. Over-expression of miR-27b inhibits the expression of CREB1. |
Wang et al., 2015 |
| Gastric cancer |
AGS |
Up |
APC |
Wnt signaling pathway |
MicroRNA-27 regulates epithelial-mesenchymal transition in gastric cancer by activating the Wnt pathway. |
Zhang et al., 2011 |
| Breast cancer |
MCF-7, MDA-MB-231, MCF-10A |
Up |
BAK |
BAK-SMAC/DIABLO-XIAP pathway |
Knockdown of miR-27a enhances the sensitivity of breast cancer cells to cisplatin treatment through BAK-SMAC/DIABLO-XIAP pathway. |
Zhou et al., 2016 |