| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Multiple sclerosis | COS-7 | Up | TGFBR1 | TGF-beta signaling pathway | Upregulation of miR-27b downregulates the expression of TGFBR1. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-27b suppresses the expression of SMAD4. MicroRNA-27b targets TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Gastric cancer | Gastric cancer tissue | FZD7 | Wnt signaling pathway | Upregulation of miR-27b suppresses H. pylori infection-induced cell proliferation and WNT signaling pathway activation in gastric cancer cells. | Geng et al., 2016 | |
| Gastric cancer | MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 | Down | ROR1 | Jak-STAT signaling pathway | MicroRNA-27b acts as a tumor-suppressor through the inhibition of oncogene ROR1 expression in gastric cancer. | Tao et al., 2015 |
| Gastric cancer | Stomach | CREB1 | CREB signaling pathway | Upregulation of CREB1 is associated with lymph node metastasis, distant metastasis and tumor stage and poor outcome in gastric cancer. Over-expression of miR-27b inhibits the expression of CREB1. | Wang et al., 2015 |