| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| B-cell non-Hodgkin lymphoma | Germinal Center B cells | Down | BAG1 | ERK pathway | hsa-miR-28 targets BCL2-associated athanogene (BAG1) involved in proliferation and apoptosis. BAG1 is an activator of the ERK pathway. | Schneider et al., 2014 |
| Hepatocellular carcinoma | Hepatocyte | Down | IGF1 | PI3K-Akt signaling pathway | Decreased expression of miR-28 is associated with tumor growth via PI3K-Akt signaling pathway by down-regulating IGF1 in hepatocellular carcinoma. | Shi et al., 2015 |
| Hepatocellular carcinoma | Hepatocyte | IGF1 | PI3K-Akt signaling pathway | hsa-miR-28 directly targets the expression of insulin-like growth factor 1. Downregulation of miR-28 is associated with tumor proliferation and migration through PI3K-Akt signaling pathway by targeting IGF1. | Shi et al., 2015 |