| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Influenza virus A infection | A-549 | Up | DNMT | Protein kinase A signaling pathway | MicroRNA miR29 inhibits DNMT activity and regulates expression of COX2 and PGE2. Protein kinase A signaling pathway activation and CREB1 phosphorylation also associated to expression of COX2. | Fang et al., 2012 |
| Gastric cancer | - | Up | AKT | PI3K-Akt signaling pathway | The miR-29b controls cisplatin resistance of gastric cancer cell by suppressing PI3K-Akt signaling pathway. | Chen et al., 2015 |
| Breast cancer | Breast | Up | PTEN | PI3K-Akt signaling pathway | MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting PTEN in breast cancer cells. | Shen et al., 2016 |
| Breast cancer | Breast | Up | GSK 3 BETA | PI3K-Akt signaling pathway | MicroRNA-29a promotes adriamycin resistance via PTEN/AKT/GSK3-beta pathway through targeting GSK3-beta in breast cancer cells. | Shen et al., 2016 |
| Hepatocellular carcinoma | LX-1, HSC-T6 | Down | PIK3R1 | PI3K-Akt signaling pathway | hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs). | Wang et al., 2015 |
| Hepatocellular carcinoma | LX-1, HSC-T6 | Down | AKT3 | PI3K-Akt signaling pathway | hsa-miR-29b directly targets PIK3R1 and AKT3, causing inactivation of PI3K-Akt signaling pathway and inducting apoptosis of hepatic stellate cells (HSCs). | Wang et al., 2015 |
| Colorectal cancer | SW620, LoVo | Down | GNA13 | Beta-catenin pathway | miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating GNA13. | Zhang et al., 2014 |
| Colorectal cancer | SW620, LoVo | Down | PTP4A | Beta-catenin pathway | miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating PTP4A. | Zhang et al., 2014 |
| Prostate cancer | DU145, PC-3 | Down | LAMC1 | Laminin signaling pathway | MicroRNA-29a functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway. | Nishikawa et al., 2014 |
| Prostate cancer | DU145, PC-3 | Down | LAMC1 | Laminin signaling pathway | MicroRNA-29b functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway | Nishikawa et al., 2014 |
| Prostate cancer | DU145, PC-3 | Down | LAMC1 | Laminin signaling pathway | MicroRNA-29c functions as tumor suppressors and promotes cancer cell migration and invasion through down-regulating laminin signaling pathway | Nishikawa et al., 2014 |
| Bladder cancer | T24 | Down | PI3K-Akt signaling pathway | MicroRNA-29c suppresses proliferation in human bladder cancer cell proliferation through PI3K-PI3K-Akt signaling pathway. | Fan et al., 2014 |