Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Breast cancer | Breast | Down | MEKK1 | ERK pathway | MicroRNA-302 sensitizes breast cancer cells to adriamycin through targeting P-glycoprotein by inhibiting MEKK1 of ERK pathway. | Zhao et al., 2016 |
Hepatocellular carcinoma | Hepatocyte | Down | EGFR | EGFR signaling pathway | MicroRNA-302b targets EGFR, and the cell cycle progression is arrested at the G0/G1-phase. At the same time, the expression of AKT2 is down-regulated, and CCND1 and CDK2 are reduced by miR-302b. Thus, overexpression of miR-302b inhibits the growth of hepatoma cells may due to targeting the EGFR/AKT2/CCND1 pathway. | Wang et al., 2014 |
Prostate cancer | DU145, PC-3, 22Rv1 | Down | AKT | PI3K-Akt signaling pathway | MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway in prostate cancer. | Zhang et al., 2015 |
Prostate cancer | DU145, PC-3, 22Rv1 | Down | AKT | PI3K-Akt signaling pathway | MicroRNA-302a suppresses AKT expression which causes subsequent change in the PI3K-Akt signaling pathway. | Zhang et al., 2015 |
Ovarian cancer | SK-OV-3, OVCAR3 | Down | RUNX1 | Jak-STAT signaling pathway | MicroRNA-302b acts as a tumor suppressor in epithelial ovarian cancer by down-regulating RUNX1 expression and regulating the Jak-STAT signaling pathway. | Ge et al., 2014 |
Fanconi anemia | NCC-IT | FANCD2 | Fanconi anemia pathway | Upregulation of miR-302 plays an important role in monoubiquitination of fanconi anemia pathway member FANCD2. | Suresh et al., 2015 |