| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | Hepatocyte | Down | EGFR | EGFR signaling pathway | MicroRNA-302b targets EGFR, and the cell cycle progression is arrested at the G0/G1-phase. At the same time, the expression of AKT2 is down-regulated, and CCND1 and CDK2 are reduced by miR-302b. Thus, overexpression of miR-302b inhibits the growth of hepatoma cells may due to targeting the EGFR/AKT2/CCND1 pathway. | Wang et al., 2014 |
| Ovarian cancer | SK-OV-3, OVCAR3 | Down | RUNX1 | Jak-STAT signaling pathway | MicroRNA-302b acts as a tumor suppressor in epithelial ovarian cancer by down-regulating RUNX1 expression and regulating the Jak-STAT signaling pathway. | Ge et al., 2014 |