Chronic lymphocytic leukemia |
Peripheral blood |
Up |
|
p53 signaling pathway |
MicroRNA-34a is proposed as a marker for the activity of the p53 signaling pathway in chronic lymphocytic leukemia. |
Merkel et al., 2010 |
Alzheimer's disease |
SH-SY5Y |
Down |
|
ERK pathway |
MicroRNA-34a and its regulator TAp73 play an important role in tight regulation of the neuronal cell cycle via their ability to reduce cyclin D1. This balance is significantly altered when neurons encounter insults like A-beta-42, which aberrantly activates MEK-ERK signaling. |
Modi et al., 2015 |
Gastric cancer |
Stomach |
Down |
PDGFR |
PI3K-Akt signaling pathway |
MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating PDGFR via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway. |
Peng et al., 2014 |
Gastric cancer |
Stomach |
Down |
MET |
PI3K-Akt signaling pathway |
MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating the expression of MET via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway. |
Peng et al., 2014 |
Gastric cancer |
SGC-7901 |
Down |
|
PI3K-Akt signaling pathway |
Upregulation of miR-34a promotes sensitivity of gastric cancer cells against cisplatin-based chemotherapies through PI3K-Akt signaling pathway. |
Cao et al., 2014 |
Non-alcoholic fatty liver disease |
L-02 |
Up |
SIRT1 |
Lipid metabolism pathway |
Overexpression of miR-34a suppresses the expression of SIRT1. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease. |
Ding et al., 2015 |
Non-alcoholic fatty liver disease |
L-02 |
Up |
PPARA |
Lipid metabolism pathway |
Overexpression of miR-34a suppresses the expression of PPAR-alpha. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease. |
Ding et al., 2015 |
Non-alcoholic fatty liver disease |
Hepatocyte |
Up |
HNF4 ALPHA |
Lipid metabolism pathway |
MicroRNA-34a suppresses very low-density lipoprotein secretion and induces liver steatosis and hypolipidemia through the miR-34a-HNF4-alpha pathway. |
Xu et al., 2015 |
Lung cancer |
|
|
AXL |
JNK signaling pathway |
AXL is autoregulated by miR-34a in a feedback loop and promotes apoptosis in lung cancer cells. |
Cho et al., 2016 |
Breast cancer |
Breast |
Down |
WNT 1 |
Wnt signaling pathway |
MicroRNA-34a inhibits the proliferation and progression of breast cancer through modulating the Wnt signaling pathway. |
Si et al., 2016 |
Breast cancer |
MCF-7, MDA-MB-231, MDA-MB-453 |
Down |
TPD52 |
TPD52 pathway |
MicroRNA-34a suppresses breast cancer progression and metastasis via inhibiting TPD52. |
Li et al., 2016 |
Breast cancer |
MCF-7 |
Down |
NOTCH1 |
Notch signaling pathway |
MicroRNA-34a suppresses breast cancer stemness and enhances the chemosensitivity to paclitaxel by targeting the Notch1 pathway. |
Kang et al., 2015 |
Hepatocellular carcinoma |
Hep-G2, Huh-7 |
Down |
LDHA |
Glycolysis pathway |
In hepatocellular cancer cells, upregulation of miR-34a suppresses the expression of lactate dehydrogenase A (LDHA), which is a key enzyme in the glycolysis signaling pathway. |
Li et al., 2016 |
Hepatocellular carcinoma |
Hep-G2 |
Up |
BETA CATENIN |
Wnt signaling pathway |
Over-expression of miR-34a inhibits the expression of Wnt signaling pathway by down-regulating beta-catenin. |
Zhu et al., 2015 |
Hepatocellular carcinoma |
Hepatocyte |
Down |
FOX M1 |
Myc pathway |
hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma. |
Xu et al., 2015 |
Hepatocellular carcinoma |
Hepatocyte |
Down |
MYC |
Myc pathway |
hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma. |
Xu et al., 2015 |
Cervical cancer |
HeLa, Ca Ski, SiHa |
Down |
NOTCH1 |
Notch signaling pathway |
MicroRNA-34a suppresses invasiveness in cervical cancer through targeting the Notch pathway. |
Pang et al., 2010 |
Choriocarcinoma |
BeWo, JAR |
Down |
NOTCH1 |
Notch signaling pathway |
MicroRNA-34a suppresses invasiveness in choriocarcinoma through targeting the Notch pathway. |
Pang et al., 2010 |
Prostate cancer |
LNCaP, DU145, PC-3 |
Down |
ATG4B |
mTOR pathway |
MicroRNA-34a increases chemosensitivity in prostate cancer by inhibiting ATG4B-induced autophagy via AMPK/mTOR pathway. |
Liao et al., 2016 |
Bladder cancer |
T24, 5637 |
Down |
HNF4G |
miR-34a-HNF4G pathway |
MicroRNA-34a suppresses tumor cell viability, colony formation, and invasion in bladder cancer by targeting HNF4G. |
Sun et al., 2015 |
Papillary thyroid carcinoma |
TPC-1 |
Up |
GAS1 |
PI3K-Akt signaling pathway |
MicroRNA-34a enhances proliferation and inhibits apoptosis in papillary thyroid carcinoma by targeting GAS1 through PI3K-Akt signaling pathway. |
Ma et al., 2013 |