microRNA Name:

hsa-miR-34a

Gene Score: 0.064

Pathway Score: 0.1721

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Chronic lymphocytic leukemia Peripheral blood Up p53 signaling pathway MicroRNA-34a is proposed as a marker for the activity of the p53 signaling pathway in chronic lymphocytic leukemia.
Merkel et al., 2010
Alzheimer's disease SH-SY5Y Down ERK pathway MicroRNA-34a and its regulator TAp73 play an important role in tight regulation of the neuronal cell cycle via their ability to reduce cyclin D1. This balance is significantly altered when neurons encounter insults like A-beta-42, which aberrantly activates MEK-ERK signaling.
Modi et al., 2015
Gastric cancer Stomach Down PDGFR PI3K-Akt signaling pathway MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating PDGFR via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway.
Peng et al., 2014
Gastric cancer Stomach Down MET PI3K-Akt signaling pathway MicroRNA-34a suppresses gastric cancer tumourigenesis by down-regulating the expression of MET via the PI3K (phosphoinositide 3-kinase)/PI3K-Akt signaling pathway.
Peng et al., 2014
Gastric cancer SGC-7901 Down PI3K-Akt signaling pathway Upregulation of miR-34a promotes sensitivity of gastric cancer cells against cisplatin-based chemotherapies through PI3K-Akt signaling pathway.
Cao et al., 2014
Non-alcoholic fatty liver disease L-02 Up SIRT1 Lipid metabolism pathway Overexpression of miR-34a suppresses the expression of SIRT1. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease.
Ding et al., 2015
Non-alcoholic fatty liver disease L-02 Up PPARA Lipid metabolism pathway Overexpression of miR-34a suppresses the expression of PPAR-alpha. Down-regulation of miR-34a is associated with altered lipid metabolism in non-alcoholic fatty liver disease.
Ding et al., 2015
Non-alcoholic fatty liver disease Hepatocyte Up HNF4 ALPHA Lipid metabolism pathway MicroRNA-34a suppresses very low-density lipoprotein secretion and induces liver steatosis and hypolipidemia through the miR-34a-HNF4-alpha pathway.
Xu et al., 2015
Lung cancer AXL JNK signaling pathway AXL is autoregulated by miR-34a in a feedback loop and promotes apoptosis in lung cancer cells.
Cho et al., 2016
Breast cancer Breast Down WNT 1 Wnt signaling pathway MicroRNA-34a inhibits the proliferation and progression of breast cancer through modulating the Wnt signaling pathway.
Si et al., 2016
Breast cancer MCF-7, MDA-MB-231, MDA-MB-453 Down TPD52 TPD52 pathway MicroRNA-34a suppresses breast cancer progression and metastasis via inhibiting TPD52.
Li et al., 2016
Breast cancer MCF-7 Down NOTCH1 Notch signaling pathway MicroRNA-34a suppresses breast cancer stemness and enhances the chemosensitivity to paclitaxel by targeting the Notch1 pathway.
Kang et al., 2015
Hepatocellular carcinoma Hep-G2, Huh-7 Down LDHA Glycolysis pathway In hepatocellular cancer cells, upregulation of miR-34a suppresses the expression of lactate dehydrogenase A (LDHA), which is a key enzyme in the glycolysis signaling pathway.
Li et al., 2016
Hepatocellular carcinoma Hep-G2 Up BETA CATENIN Wnt signaling pathway Over-expression of miR-34a inhibits the expression of Wnt signaling pathway by down-regulating beta-catenin.
Zhu et al., 2015
Hepatocellular carcinoma Hepatocyte Down FOX M1 Myc pathway hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma.
Xu et al., 2015
Hepatocellular carcinoma Hepatocyte Down MYC Myc pathway hsa-miR-34a downregulates the expression of FoxM1 and c-Myc, which promotes telomerase activity and extends telomerase length in hepatocellular carcinoma.
Xu et al., 2015
Cervical cancer HeLa, Ca Ski, SiHa Down NOTCH1 Notch signaling pathway MicroRNA-34a suppresses invasiveness in cervical cancer through targeting the Notch pathway.
Pang et al., 2010
Choriocarcinoma BeWo, JAR Down NOTCH1 Notch signaling pathway MicroRNA-34a suppresses invasiveness in choriocarcinoma through targeting the Notch pathway.
Pang et al., 2010
Prostate cancer LNCaP, DU145, PC-3 Down ATG4B mTOR pathway MicroRNA-34a increases chemosensitivity in prostate cancer by inhibiting ATG4B-induced autophagy via AMPK/mTOR pathway.
Liao et al., 2016
Bladder cancer T24, 5637 Down HNF4G miR-34a-HNF4G pathway MicroRNA-34a suppresses tumor cell viability, colony formation, and invasion in bladder cancer by targeting HNF4G.
Sun et al., 2015
Papillary thyroid carcinoma TPC-1 Up GAS1 PI3K-Akt signaling pathway MicroRNA-34a enhances proliferation and inhibits apoptosis in papillary thyroid carcinoma by targeting GAS1 through PI3K-Akt signaling pathway.
Ma et al., 2013