| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Gastric cancer | BGC-823,AGS, SGC-7901, MKN-45 | Down | JAK2 | Jak-STAT signaling pathway | MicroRNA-375 suppresses Helicobacter pylori-induced gastric carcinogenesis by inhibiting Jak-STAT signaling pathway. | Miao et al., 2014 |
| Gastric cancer | Stomach | Down | PDK1 | PDK1 signaling | MicroRNA-375 controls cell survival through suppressing PDK1 in gastric cancer. | Tsukamoto et al., 2010 |
| Colorectal cancer | HCT 116 | BCL 2 | BCL-2 pathway | MicroRNA-375 acts as a key player in regulating the pathways responsible for inhibiting the natural history of colorectal cancer tumor cells, through the Bcl-2 pathway. | Zaharie et al., 2015 |