| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Breast cancer | MCF-7, MDA-MB-231 | RUNX1 | PPAR signaling pathway | Ectopic expression of microRNA-378 down-regulates Runx1 and inhibits migration and invasion in breast cancer. | Browne et al., 2016 | |
| Breast cancer | HeLa | Up | AURORA B | MAPK signaling pathway | Overexpression of hsa-miR-378a activates MAPK signaling pathway and is associated with downregulation of Aurora B kinase. Excess miR-378a level is associated with the most aggressive, poorly differentiated forms of breast cancer. | Winsel et al., 2014 |