| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatitis C virus infection | Hep-G2 | Down | IL 6 | IL-6-mediated signaling pathway | MicroRNA-449a regulates IL-6-mediated CCL2 expression and STAT3 phosphorylation by down-regulating IL-6R. | Sarma et al., 2014 |
| Hepatitis C virus infection | Hep-G2 | Down | NOTCH1 | Notch signaling pathway | MicroRNA-449a plays an important role in regulating the expression of YKL40 through down-regulating NOTCH1 which is the components of the NOTCH signaling pathway. | Sarma et al., 2012 |
| Gastric cancer | SNU-638 | Down | p53 signaling pathway | MicroRNA-449 promotes senescence and apoptosis through activating the p53 signaling pathway. | Bou et al., 2011 | |
| Hepatocellular carcinoma | Hepatocyte | SIRT1 | SREBP pathway | MicroRNA-449 inhibits SIRT1-SREBP signaling via downregulating expression of SIRT1 and re-programs lipogenesis and cholesterogenesis in hepatocellular carcinoma. | Zhang et al., 2014 | |
| Papillary thyroid carcinoma | TPC-1, K1, IHH-4, CGTH-W-3 | Down | RET | Beta-catenin pathway | Up regulation of miR-449 suppresses the growth of papillary thyroid carcinoma by targeting the beta-catenin pathway. | Li et al., 2016 |