| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| T-cell acute lymphoblastic leukemia | T-ALL cell lines | Down | MYC | Notch signaling pathway | hsa-miR-451 acts as a suppressor of tumor initiation by downregulating the expression of MYC in acute lymphoblastic leukemia. | Li et al., 2011 |
| Multiple myeloma | Multiple myeloma cell lines | Up | TSC1 | PI3K-Akt signaling pathway | MicroRNA-451 down-regulates TSC1 to mediate PI3K/Akt/mTOR signaling, which plays an important role in myeloma stem cell biology. | Du et al., 2015 |
| Gastric cancer | MKN28, MKN45, AGS | Down | TSC1 | PI3K-Akt signaling pathway | MicroRNA-101-2 act as potential tumor suppressors by down-regulating the expression of TSC1 in gastric cancer. | Riquelme et al., 2016 |
| Non-alcoholic fatty liver disease | Hep-G2 | Down | CAB39 | PI3K-Akt signaling pathway | Decreased expression of microRNA-451 is associated with suppression fatty acid-induced proinflammatory cytokine production via the AMPK/PI3K-Akt signaling pathway. | Hur et al., 2015 |
| Breast cancer | MCF-7 | Down | MIF | MIF signaling pathway | Upregulation of miR-451a suppresses MIF expression and inhibits cell proliferation, colony formation, and invasion of breast cancer cells. | Liu et al., 2015 |
| Cervical cancer | HeLa, HUVEC, RKO | Down | IL6R | IL6R pathway | MicroRNA-451 function as a tumor suppressor by down-regulating the IL6R pathway. | Liu et al., 2014 |
| Colorectal cancer | HeLa, HUVEC, RKO | Down | IL6R | IL6R pathway | MicroRNA-451 function as a tumor suppressor by down-regulating the IL6R pathway. | Liu et al., 2014 |
| Nasopharyngeal carcinoma | NP69 | Down | MIF | MIF signaling pathway | Over-expression of miR-451 inhibits cell viability, colony formation, and cell migration and invasion by targeting MIF. | Liu et al., 2013 |