| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Sezary syndrome | HuT 78, H9, HH | Up | PTEN | PI3K-Akt signaling pathway | Overexpression of hsa-miR-486 downregulates the expression of PTEN. Reduced PTEN activates the PI3/AKT-mediated pathway of cell growth and survival. | Cristofoletti et al., 2013 |
| Hepatocellular carcinoma | Hepatocyte | Down | PIK3R1 | PI3K-Akt signaling pathway | hsa-miR-486 inhibits hepatocellular carcinoma cell proliferation by downregulating PIK3R1 expression and suppressing PI3K-Akt signaling pathway activation. | Huang et al., 2015 |