| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Breast cancer | Breast | Down | SPIN1 | PI3K-Akt signaling pathway | MicroRNA-489 reverses the chemoresistance of breast cancer through the PI3K-PI3K-Akt signaling pathway by inhibiting SPIN1 expression. | Chen et al., 2016 |
| Breast cancer | MCF-7 | Down | HER2 | MAPK signaling pathway | A double-negative feedback loop of miR-489 and the HER2-SHP2-MAPK signaling axis promotes breast cancer cell proliferation and tumor progression. | Patel et al., 2016 |
| Osteosarcoma | Bone | Down | PAX3 | c-MET signaling pathway | MicroRNA-489 suppresses osteosarcoma metastasis by inhibiting PAX3 expression. | Liu et al., 2016 |