Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Hepatitis C virus infection | Huh-7 | Down | AKT | PI3K-Akt signaling pathway | MicroRNA-491 represses the phosphoinositol-3 (PI3) kinase/PI3K-Akt signaling pathway. | Ishida et al., 2011 |
Hepatocellular carcinoma | Hepatocyte | Down | GIT 1 | NF-Kappa B signaling pathway | Overexpression of hsa-miR-491 blocks the activation of GIT-1 mediated ERK which inactivate NF-Kappa B signaling pathway | Yang et al., 2016 |
Cervical cancer | HeLa, SiHa, MS751 | Down | HTERT | PI3K-Akt signaling pathway | MicroRNA-491 inhibits cervical cancer cell growth through PI3K-Akt signaling pathway by down-regulating human telomerase reverse transcriptase (hTERT) expression. | Zhou et al., 2016 |