| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Breast cancer | HUVEC | VEGFR2 | PI3K-Akt signaling pathway | MicroRNA-497 suppresses tumor angiogenesis and growth through down-regulating VEGFR2 expression in breast cancer. | Tu et al., 2015 | |
| Prostate cancer | PC-3 | Down | IKK BETA | NF-Kappa B signaling pathway | MicroRNA-497 acts as a tumor suppressor in prostate cacer by targeting IKK-beta through NF-Kappa B signaling pathway. | Kong et al., 2015 |
| Atherosclerosis | HUVEC | Up | BCL2 | Caspase 3 pathway | MiR-497 plays an important role in the development of atherosclerosis by inducing apoptosis via caspase3 pathway. | Wu et al., 2016 |
| Atherosclerosis | HUVEC | Up | CCND2 | Caspase 3 pathway | MiR-497 significantly inhibits cell proliferation by arresting the cell cycle through the CCND2 protein and induces apoptosis through the caspase3 pathway. | Wu et al., 2016 |