| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Multiple sclerosis | COS-7 | Up | TGFBR1 | TGF-beta signaling pathway | Over-expression of miR-500a downregulates the expression of TGFBR1. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |
| Multiple sclerosis | COS-7 | Up | SMAD4 | TGF-beta signaling pathway | Upregulation of miR-500a targets SMAD4. MicroRNA-500a negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis. | Severin et al., 2016 |