microRNA Name:

hsa-miR-7

Gene Score: 0.0244

Pathway Score: 0.0656

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Chronic lymphocytic leukemia Peripheral blood Down IKK BETA NF-Kappa B signaling pathway miR-708 regulates the NF-Kappa B signaling pathway by targeting IKK beta (inhibitor of kappa light polypeptide gene enhancer in B cell) in chronic lymphocytic leukemia.
 Baer et al., 2015
Parkinson's disease SH-SY5Y Up KEAP1 Nrf2 signaling pathway MicroRNA-7 is upregulated in the brain, suppresses the expression of Keap1 in human neuroblastoma cells. Subsequently, this event activates Nrf2 pathway.
 Kabaria et al., 2015
Parkinson's disease SH-SY5Y Up REL A Glycolysis pathway MicroRNA-7 increases Glut3 expression, promotes glycolysis, and subsequently inhibits MPP(+)-induced cell death by targeting RelA.
 Chaudhuri et al., 2015
Parkinson's disease HEK293 Up ALPHA SYNUCLEIN mTOR pathway MicroRNA-7 protects neurons from cell death by interfering with the MPP+-induced suppression of mTOR signaling pathway.
 Fragkouli et al., 2014
Multiple sclerosis COS-7 Up SMAD4 TGF-beta signaling pathway Upregulation of miR-708 inhibits the expression of SMAD4. MicroRNA-708 negatively regulates TGF-beta signaling, and dampens the development of regulatory T cell, thereby increasing susceptibility to developing multiple sclerosis.
 Severin et al., 2016
Cervical cancer HeLa, C-4-1, Ca Ski, SiHa Up BCL 2 Apoptosis pathway MicroRNA-744 suppresses the expression of Bcl-2, which leads to the inactivation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorating cervical cancer growth and progression.
 Chen et al., 2016
Laryngeal squamous cell carcinoma Lung Up PDCD4 NF-Kappa B signaling pathway Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating NF-Kappa B signaling pathway.
 Li et al., 2016
Laryngeal squamous cell carcinoma Lung Up PTEN mTOR pathway Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating AKT/mTOR signaling pathway.
 Li et al., 2016
Metastatic lung cancer Lung Down P21 PI3K-Akt signaling pathway Upregulation of the miRNA-708 inhibits cell survival and metastasis through its direct target p21, and suppresses the PI3K-Akt signaling pathway and stem cell-like characteristics of lung cancer cells.
 Wu et al., 2016
Non-small cell lung cancer Lung SMARCD1 Apoptosis pathway MicroRNA-7 suppresses p53-dependent apoptosis-related gene BAX (BCL2-associated X protein) and expression of p21 by interfering with the interaction between SMARCD1 and p53, thereby decreasing caspase3 cleavage and the downstream apoptosis cascades.
 Hong et al., 2016
Triple negative breast cancer MDA-MB-231 RAF 1 Raf signaling pathway Decreased expression of miR-7 by lapatinib is associated with the activation of Raf-1 signaling pathway in triple-negative breast cancer.
 Hsiao et al., 2015
Prostate cancer PC-3 Down KLF4 PI3K-Akt signaling pathway MicroRNA-7 suppresses the stemness of prostate cancer stem-like cells and tumorigenesis through inhibiting KLF4/PI3K/Akt/p21 pathway.
 Chang et al., 2015
Ovarian cancer Ovary Down EGFR PI3K-Akt signaling pathway MicroRNA-7 suppresses tumor metastasis via PI3K-Akt signaling pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.
 Zhou et al., 2014
Ovarian cancer Ovary Down EGFR ERK pathway MicroRNA-7 suppresses tumor metastasis via ERK1/2 pathway inactivation by inhibiting EGFR expression in epithelial ovarian cancer.
 Zhou et al., 2014
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up SFRP1 Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting secreted frizzled-related protein 1 (SFRP1), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up GSK 3 BETA Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up TLE3 Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting transducin-like enhancer of split 3 (TLE3), important negative regulator of Wnt signaling pathway.
 Zhou et al., 2015


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024