microRNA Name:

hsa-miR-744

Gene Score: 0.0183

Pathway Score: 0.0492

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Cervical cancer HeLa, C-4-1, Ca Ski, SiHa Up BCL 2 Apoptosis pathway MicroRNA-744 suppresses the expression of Bcl-2, which leads to the inactivation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorating cervical cancer growth and progression.
Chen et al., 2016
Laryngeal squamous cell carcinoma Lung Up PDCD4 NF-Kappa B signaling pathway Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating NF-Kappa B signaling pathway.
Li et al., 2016
Laryngeal squamous cell carcinoma Lung Up PTEN mTOR pathway Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating AKT/mTOR signaling pathway.
Li et al., 2016
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up SFRP1 Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting secreted frizzled-related protein 1 (SFRP1), important negative regulator of Wnt signaling pathway.
Zhou et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up GSK 3 BETA Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway.
Zhou et al., 2015
Pancreatic carcinoma PANC-1, BxPC-3, CFPAC-1, Capan-1 Up TLE3 Wnt signaling pathway MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting transducin-like enhancer of split 3 (TLE3), important negative regulator of Wnt signaling pathway.
Zhou et al., 2015