Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Cervical cancer | HeLa, C-4-1, Ca Ski, SiHa | Up | BCL 2 | Apoptosis pathway | MicroRNA-744 suppresses the expression of Bcl-2, which leads to the inactivation of apoptosis signaling and the cell proliferation of cervical cancer cells, ameliorating cervical cancer growth and progression. | Chen et al., 2016 |
Laryngeal squamous cell carcinoma | Lung | Up | PDCD4 | NF-Kappa B signaling pathway | Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating NF-Kappa B signaling pathway. | Li et al., 2016 |
Laryngeal squamous cell carcinoma | Lung | Up | PTEN | mTOR pathway | Down-regulation of miR-744 is associated with suppression of laryngeal squamous cell carcinoma metastasis by inactivating AKT/mTOR signaling pathway. | Li et al., 2016 |
Pancreatic carcinoma | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | SFRP1 | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting secreted frizzled-related protein 1 (SFRP1), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
Pancreatic carcinoma | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | GSK 3 BETA | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting glycogen synthase kinase 3-beta (GSK3-beta), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |
Pancreatic carcinoma | PANC-1, BxPC-3, CFPAC-1, Capan-1 | Up | TLE3 | Wnt signaling pathway | MicroRNA-744 promotes tumorigenicity in pancreatic cancer by directly targeting transducin-like enhancer of split 3 (TLE3), important negative regulator of Wnt signaling pathway. | Zhou et al., 2015 |