microRNA Name:

hsa-miR-9

Gene Score: 0.0457

Pathway Score: 0.123

Disease Tissue/ Cell line MicroRNA regulation Targeted Member Pathway More Details References
Hodgkin lymphoma KM-H2, L-428, L-1236, SUP-HD1 Up FOXO1 ERK pathway hsa-miR-96 downregulates the expression of FOXO1. Ectopic expression of a constitutively active FOXO1 promotes apoptosis and blocks proliferation in classical hodgkin lymphoma.
 Xie et al., 2012
Primary CNS lymphoma Lymph node Up Myc pathway Overexpression of hsa-miR-9 activates Myc pathway in primary CNS lymphomas.
 Fischer et al., 2011
Acute lymphoblastic leukemia TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat Down CDK6 CDK pathway CDK6 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the CDK6-RB1 oncogenic pathway in acute lymphoblastic leukemia.
 Rodriguez-Otero et al., 2011
Acute lymphoblastic leukemia TOM-1, NALM-20, Loucy, MY, Tanoue, Jurkat Down FGFR1 FGF signaling pathway FGFR1 is the direct targets of miR-9 and the epigenetic silencing of the tumour-suppressor gene miR-9 promotes cell proliferation by the activation of the FGFR1 oncogenic pathway in acute lymphoblastic leukemia.
 Rodriguez-Otero et al., 2011
Chronic lymphocytic leukemia Peripheral blood Down NF KAPPA B NF-Kappa B signaling pathway Up-regulation of miR-9-3 suppresses cell proliferation and enhances apoptosis in association with downregulation of NF-Kappa B1 in chronic lymphocytic leukemia.
 Wang et al., 2013
Pancreatic carcinoma SW1990 Up GSK 3 BETA Wnt signaling pathway Over-expression of miR-940 significantly represses GSK3-beta expression and enhances pancreatic carcinoma proliferation and invasion.
Yang et al., 2016
Pancreatic carcinoma SW1990 Up SFRP1 Wnt signaling pathway Over-expression of miR-940 significantly represses sFRP1 expression and enhances pancreatic carcinoma proliferation and invasion.
Yang et al., 2016
Gastric cancer Gastric cancer tissue Down CUL4A Hippo signaling pathway Upregulation of miR-9 inhibits the CUL4A-LATS1-Hippo signaling pathway and represses gastric cancer cell proliferation and invasion.
 Deng et al., 2016
Gastric signet ring cell carcinoma GES-1, AGS, MKN28, MKN45, KATO III, SGC-7901 Down NOTCH1 Notch signaling pathway MicroRNA-935 suppresses gastric carcinoma cell proliferation, migration and invasion by directly inhibiting the expression of Notch1.
 Yan et al., 2016
Gastric cancer AGS, SNU-16 Up E2F1 TGF-beta signaling pathway MicroRNA-93 alters the TGF-beta tumor suppressor pathway in gastric cancer.
 Petrocca et al., 2008
Lung cancer A-549, MRC-5 ZNRF3 Wnt signaling pathway MicroRNA-93 functions as an oncogenic microRNA for lung cancer progression through inhibiting Wnt signaling pathway.
 Shi et al., 2016
Non-small cell lung cancer Lung Down IGF 1R IGF signaling pathway MicroRNA-99a promotes proliferation, colony formation and migration through the IGF-1R pathway in non-small cell lung cancer.
 Chen et al., 2015
Non-small cell lung cancer Lung Down AKT AKT1 signaling pathway MicroRNA-99a plays an important role in the tumorigenesis and metastasis of non-small cell lung cancer by inhibiting AKT1 signaling pathway.
 Yu et al., 2015
Triple negative breast cancer MDA-MB-231 Up NOTCH1 Notch signaling pathway MicroRNA-9 elicits a suppressor-like activity in metastatic breast cancer cells by targeting Notch1.
 Mohammadi-Yeganeh et al., 2015
Hepatocellular carcinoma Hepatocyte Up CDH1 PPAR signaling pathway hsa-miR-9 controls CDH1 expression through directly targeting CDH1 and indirectly through PPARA. hsa-miR -9 is the key regulator of HCC oncogenesis via PPAR signaling pathway.
 Drakaki et al., 2015
Hepatocellular carcinoma Hepatocyte Up PPARA PPAR signaling pathway hsa-miR-9 controls CDH1 expression through directly targeting CDH1 and indirectly through PPARA. hsa-miR -9 is the key regulator of HCC oncogenesis via PPAR signaling pathway.
 Drakaki et al., 2015
Hepatocellular carcinoma Hepatocyte TAZ PI3K-Akt signaling pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through PI3K-Akt signaling pathway.
 Higashi et al., 2015
Hepatocellular carcinoma Hepatocyte TAZ ERK pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through ERK pathway.
 Higashi et al., 2015
Hepatocellular carcinoma Hepatocyte TAZ Beta-catenin pathway Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through Beta-catenin pathway.
 Higashi et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGF 1R IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGF-1R of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGFBP 3 IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGFBP-3 of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Up IGF-II IGF signaling pathway Overexpression of hsa-miR-96 shows a significant downregulation of IGF-II of oncogenic IGF signaling pathway in hepatocellular carcinoma.
 Assal et al., 2015
Hepatocellular carcinoma Hepatocyte Up PTEN PI3K-Akt signaling pathway hsa-miR-93 suppresses the expression of PTEN, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
Hepatocellular carcinoma Hepatocyte Up CDKN1A PI3K-Akt signaling pathway hsa-miR-93 suppresses the expression of CDKN1A, thereby regulating hepatocellular carcinoma cell apoptosis and c-Met/PI3K-Akt signaling pathway activity.
 Ohta et al., 2015
Breast cancer MCF-7, MDA-MB-231 Down MTOR mTOR pathway MicroRNA-99a inhibits the breast cancer malignant cancer stem cell phenotype by suppressing the mTOR signaling pathway.
 Yang et al., 2014
Cervical cancer HeLa Down MTOR mTOR pathway Increased expression of miR-99a suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.
 Wang et al., 2014
Cervical cancer HeLa Down MTOR mTOR pathway Increased expression of miR-99b suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway.
 Wang et al., 2014
Ovarian cancer A2780, SK-OV-3, Caov-3 Up APC2 Wnt signaling pathway MicroRNA-939 acts as a potential tumor promoter by regulating the Wnt signaling pathway through inhibition of APC2 expression.
 Ying et al., 2015
Ovarian cancer Ovary EZH2 E2F Signaling pathway MicroRNA-98 suppresses cell proliferation in human ovarian cancer stem cells through regulating the Rb/E2F pathway.
 Liu et al., 2014
Ovarian cancer SK-OV-3, OVCAR3, Caov-3 Down TLN1 PI3K-Akt signaling pathway MicroRNA-9 acts as a tumor suppressor in ovarian serous carcinoma by down-regulating TLN1 expression.
 Tang et al., 2014
Nasopharyngeal carcinoma CNE-1, CNE-2 Up PTEN PI3K-Akt signaling pathway MicroRNA-92a induces metastasis of nasopharyngeal carcinoma by down-regulating the PI3K-Akt signaling pathway.
 Zhang et al., 2016
Nasopharyngeal carcinoma CNE-1, CNE-2, HONE1 Up DAB2 miR-93/Dab2 pathway MicroRNA-93 enhances cell growth and invasion in nasopharyngeal carcinoma by down-regulating Dab2 expression.
 Xu et al., 2015
Nasopharyngeal carcinoma CNE-1, CNE-2 Down TGFBR2 PI3K-Akt signaling pathway MicroRNA-93 enhances uncontrolled growth, invasion, metastasis of nasopharyngeal carcinoma through activating PI3K-Akt signaling pathway by inhibiting TGF-beta-R2 expression.
 Lyu et al., 2014
Nasopharyngeal carcinoma NP69 Down CXCR4 p38 MAPK signaling pathway MicroRNA-9 acts as a tumor-suppressive microRNA by down-regulating CXCR4 expression in nasopharyngeal carcinoma.
 Lu et al., 2014
Oral squamous cell carcinoma SCC-25, SCC-9, FaDu Up NLK NF-Kappa B signaling pathway MicroRNA-92b enhances tumor growth in oral squamous cell carcinoma and activates of NF-Kappa B signaling pathway through regulating the expression of NLK.
Liu et al., 2015
Oral squamous cell carcinoma SCC-9, Tca8113 Down CXCR4 Wnt signaling pathway MicroRNA-9 suppresses oral squamous cell carcinoma cell proliferation by down-regulating CXCR4 expression through the Wnt signaling pathway.
 Yu et al., 2014
Papillary thyroid carcinoma TPC-1, K1 Up FOXO1 PI3K-Akt signaling pathway MicroRNA-96 functions as an oncogene in papillary thyroid carcinoma by down-regulating the FOXO1 expression and regulating PI3K-Akt signaling pathway.
 Song et al., 2015
Anaplastic thyroid carcinoma SW1736, ARO, FRO Down MTOR mTOR pathway MicroRNA-99a acts as a tumor suppressor and plays an important role in suppressing the tumorigenesis via targeting the mTOR/p- 4E-BP1/p-S6K1 pathway in anaplastic thyroid carcinoma.
 Huang et al., 2015
Atherosclerosis THP-1 JAK1 Jak-STAT signaling pathway MiR-9 inhibits activation of the NLRP3 inflammasome and attenuates atherosclerosis-related inflammation, through the JAK/STAT signaling pathway.
 Wang et al., 2017
Atherosclerosis THP-1 MMP13 Jak-STAT signaling pathway MiR-9 inhibits activation of the NLRP3 inflammasome and attenuates atherosclerosis-related inflammation, through the JAK/STAT signaling pathway.
 Wang et al., 2017


© Regenerative Medicine Lab, 2024.

School of Medical Science and Technology, IIT Kharagpur .

mirWay Team: Sankha Subhra Das, Pritam Saha and Nishant Chakravorty.

Indian Institute of Technology Kharagpur.

Last updated: April 04, 2024