Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
---|---|---|---|---|---|---|
Non-small cell lung cancer | Lung | Down | IGF 1R | IGF signaling pathway | MicroRNA-99a promotes proliferation, colony formation and migration through the IGF-1R pathway in non-small cell lung cancer. | Chen et al., 2015 |
Non-small cell lung cancer | Lung | Down | AKT | AKT1 signaling pathway | MicroRNA-99a plays an important role in the tumorigenesis and metastasis of non-small cell lung cancer by inhibiting AKT1 signaling pathway. | Yu et al., 2015 |
Breast cancer | MCF-7, MDA-MB-231 | Down | MTOR | mTOR pathway | MicroRNA-99a inhibits the breast cancer malignant cancer stem cell phenotype by suppressing the mTOR signaling pathway. | Yang et al., 2014 |
Cervical cancer | HeLa | Down | MTOR | mTOR pathway | Increased expression of miR-99a suppresses cell growth and invasion in cervical cancer by inhibiting mTOR signaling pathway. | Wang et al., 2014 |
Anaplastic thyroid carcinoma | SW1736, ARO, FRO | Down | MTOR | mTOR pathway | MicroRNA-99a acts as a tumor suppressor and plays an important role in suppressing the tumorigenesis via targeting the mTOR/p- 4E-BP1/p-S6K1 pathway in anaplastic thyroid carcinoma. | Huang et al., 2015 |