| Disease | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | Hep-G2, SK-BR-3 | Up | RUNX1 | Runx1 signaling | Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression. | Vivacqua et al., 2015 |
| Prostate cancer | Hep-G2, SK-BR-3 | Up | RUNX1 | Runx1 signaling | Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression. | Vivacqua et al., 2015 |
| Gastric cancer | Stomach | Down | PI3K-Akt signaling pathway | MicroRNA-144 inhibits gastric cancer progression by directly suppressing MET expression, which represses activation of the PI3K-Akt signaling pathway. | Liu et al., 2015 | |
| Lung cancer | Lung | Down | ZEB1 | Zeb1 signaling pathway | Overexpression of miR-144 inhibits non-small cell lung cancers through down-regulating Zeb1. | Pan et al., 2015 |
| Breast cancer | MCF-7,SK-BR-3 | RUNX1 | Runx1 signaling | Estrogens trigger the GPER/miR144/Runx1 transduction pathway and promotes cancer progression. | Vivacqua et al., 2015 | |
| Alpha thalassemia | Zebrafish | KLFD | Klf mediated pathway | MicroRNA-144 down-regulates the embryonic alpha-globin gene expression via suppressing klfd, an erythroid-specific Kruppel-like transcription factor. | Fu et al., 2009 | |
| Bladder cancer | RT-4, T24, DSH1 | Down | EZH2 | Wnt signaling pathway | Decreased expression of miR-144 enhances bladder cancer proliferation by down-regulating EZH2 expression through activation of Wnt signaling pathway. | Guo et al., 2014 |
| Laryngeal squamous cell carcinoma | HEp-2 | Down | IRS1 | PI3K-Akt signaling pathway | MicroRNA-144 acts as a tumor suppressor in laryngeal squamous cell carcinoma by down-regulating IRS1 expression. | Wu et al., 2016 |