Pathway Name:

p53 signaling pathway

microRNA Score: 0.0819

Gene Score: 0.0579

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Hodgkin lymphoma hsa-miR-17 Hodgkin Reed Sternberg cells Up CDKN1A Overexpression of hsa-miR-17 is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma.
Gibcus et al., 2011
Hodgkin lymphoma hsa-miR-106b Hodgkin Reed Sternberg cells Up CDKN1A Overexpression of hsa-miR-106b is associated with dysfunctional p53 signaling pathway and also to malignant phenotype in Hodgkin lymphoma.
Gibcus et al., 2011
Chronic lymphocytic leukemia hsa-miR-132 Peripheral blood Up SIRT1 Up-regulation of hsa-miR-132 down-regulates the expression of SIRT1 and induces TP53-dependent apoptosis in chronic lymphocytic leukemia.
Dal et al., 2015
B-cell chronic lymphocytic leukemia hsa-miR-15a Peripheral blood Down TP53 Over-expression of hsa-miR-15a suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis.
Fabbri et al, 2011
B-cell chronic lymphocytic leukemia hsa-miR-16-1 Peripheral blood Down TP53 Over-expression of hsa-miR-16-1 suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis.
Fabbri et al, 2011
Chronic lymphocytic leukemia hsa-miR-34a Peripheral blood Up MicroRNA-34a is proposed as a marker for the activity of the p53 signaling pathway in chronic lymphocytic leukemia.
Merkel et al., 2010
Gastric cancer hsa-miR-100 Gastric cancer tissue Up MicroRNA-100 antagonism suppresses ubiquitin-mediated p53 protein degradation by activating RNF144B, an E3 ubiquitination ligase.
Yang et al., 2016
Gastric cancer hsa-miR-18a Stomach Up IRF2 MicroRNA-18a regulates the expression of P53 by directly targeting IRF2 in gastric cancer.
Chen et al., 2016
Gastric cancer hsa-miR-149 AGS, MKN-28, MKN-45 Down ZBTB2 MicroRNA-149 acts as a tumor suppressor through down-regulating ZBTB2 in human gastric cancer.
Wang et al., 2012
Gastric cancer hsa-miR-449 SNU-638 Down MicroRNA-449 promotes senescence and apoptosis through activating the p53 signaling pathway.
Bou et al., 2011
Hepatocellular carcinoma hsa-miR-21 Hep-G2 Up HBP1 MicroRNA-21 induces hepatocellular carcinoma progression through targeting Hbp1-p53-Srebp1c pathway.
Wu et al., 2015
Non-alcoholic fatty liver disease hsa-miR-21 Hep-G2 Up HBP1 MicroRNA-21 induces hepatic lipid accumulation through targeting Hbp1-p53-Srebp1c pathway.
Wu et al., 2015
Non-alcoholic fatty liver disease hsa-miR-21 Hep-G2 Up HBP1 Downregulation of hsa-miR-21 increases expression of HBP1 and p53 and decreased lipogenesis. miR-21 stimulates hepatic lipid accumulation and cancer development through modulation of Hbp1-p53-Srebp1c pathway.
Wu et al., 2015
Gastric cancer hsa-miR-18a Stomach Up IRF2 Overexpression of hsa-miR-18a downregulates the expression of IRF2. Mir-18a modulates p53 expression by targeting IRF2 and regulates p53 signaling in gastric cancer.
Chen et al., 2016
Hepatocellular carcinoma hsa-miR-205 Hepatocyte Up USP7 Overexpression of hsa-miR-205 represses the expression of USP7. Mir-205 modulates p53 signaling pathway and cell proliferation levels in hepatocellular carcinoma cell.
Zhu et al., 2015
Hepatocellular carcinoma hsa-miR-1246 Hepatocyte NFIB p53 controls the expression of hsa-miR-1246 in hepatocellular carcinoma. hsa-miR-1246 directly targets nuclear factor I/B (NFIB). Overexpression of hsa-miR-1246 promotes cell proliferation, colony formation and apoptosis through modulating p53 signaling pathway in hepatocellular carcinoma.
Zhang et al., 2015
Ovarian cancer hsa-miR-17 Ovary LKB1 hsa-miR-17 regulates proliferation and invasion of ovarian tumor cells via targeting LKB1-p53-p21/WAF1 pathway.
Liu et al., 2015
Prostate cancer hsa-miR-340 DU145, BPH-1, PC-3 Down MDM2 MicroRNA-340 acts as a tumor suppressor via the p53 signaling pathway by inhibiting MDM2 expression in prostate cancer.
Huang et al., 2016
Bladder cancer hsa-miR-155 UM-UC-3, T24 Up DMTF1 MicroRNA-155 acts as a tumor promoter by inhibiting DMTF1 expression in bladder cancer.
Peng et al., 2015