Pathway Name:

Beta-catenin pathway

microRNA Score: 0.0345

Gene Score: 0.0244

Disease Micro RNA Tissue/ Cell line MicroRNA regulation Targeted Member More Details References
Hepatocellular carcinoma hsa-miR-655 Hep-G2, Huh-7, MHCC97-H, MHCC97-L Down ADAM10 MiR-655 acts as a tumor suppressor by directly inhibiting ADAM10 and indirectly regulating beta-catenin pathway in the development of progression of hepatocellular carcinoma.
Wu et al., 2016
Gastric cancer hsa-miR-1225 MKN28, AGS, MKN45, BGC-823, MGC-803, SGC-7901 Down IRS1 MicroRNA-1225 inhibits gastric cancer growth and metastatic potential through targeting IRS1 and beta-catenin signaling pathway.
Zheng et al., 2016
Breast cancer hsa-miR-3646 Breast Up GSK 3 BETA MicroRNA-3646 promotes docetaxel resistance of breast cancer cells via inhibiting expression of GSK-3-beta and activating GSK-3-beta/beta-catenin signaling pathway.
Zhang et al., 2016
Hepatocellular carcinoma hsa-miR-9 Hepatocyte TAZ Overexpression of hsa-miR-9 downregulates TAZ expression. Mir-9 promotes HCC cell proliferation through Beta-catenin pathway.
Higashi et al., 2015
Colorectal cancer hsa-miR-29c SW620, LoVo Down GNA13 miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating GNA13.
Zhang et al., 2014
Colorectal cancer hsa-miR-29c SW620, LoVo Down PTP4A miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating PTP4A.
Zhang et al., 2014
Cervical cancer hsa-miR-135a HeLa, Ca Ski, SiHa Up SIAH1 MicroRNA-135a promotes cervical cancer cell transformation via regulating miR-135a/SIAH1/beta-catenin signaling pathway.
Leung et al., 2014
Papillary thyroid carcinoma hsa-miR-449 TPC-1, K1, IHH-4, CGTH-W-3 Down RET Up regulation of miR-449 suppresses the growth of papillary thyroid carcinoma by targeting the beta-catenin pathway.
Li et al., 2016