| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-155 | MEC-2, BJAB | Up | QKI | LPS signaling pathway | miR-155 down-regulates expression of QKI at the onset of immune response to LPS. Overexpression of QKI increases IL-10 production, as well as the total amount of p38, while markedly impairing p38 phosphorylation. | Tili et al., 2015 |
| hsa-miR-132 | Peripheral blood | Up | SIRT1 | p53 signaling pathway | Up-regulation of hsa-miR-132 down-regulates the expression of SIRT1 and induces TP53-dependent apoptosis in chronic lymphocytic leukemia. | Dal et al., 2015 |
| hsa-miR-708 | Peripheral blood | Down | IKK BETA | NF-Kappa B signaling pathway | miR-708 regulates the NF-Kappa B signaling pathway by targeting IKK beta (inhibitor of kappa light polypeptide gene enhancer in B cell) in chronic lymphocytic leukemia. | Baer et al., 2015 |
| hsa-miR-22 | Peripheral blood | Up | PTEN | PI3K-Akt signaling pathway | Up-regulation of microRNA-22 is associated with suppression of phosphatase and tensin homolog (PTEN) and phosphoinositide 3-kinase (PI3K)/PI3K-Akt signaling pathway activation in chronic lymphocytic leukemia. | Palacios et al., 2015 |
| hsa-miR-9-3 | Peripheral blood | Down | NF KAPPA B | NF-Kappa B signaling pathway | Up-regulation of miR-9-3 suppresses cell proliferation and enhances apoptosis in association with downregulation of NF-Kappa B1 in chronic lymphocytic leukemia. | Wang et al., 2013 |
| hsa-miR-15a | Peripheral blood | Down | MCL1 | MCL1 pathway | p53 deletion results in a decrease of miR-15a, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia. | Liu et al., 2014 |
| hsa-miR-16-1 | Peripheral blood | Down | MCL1 | MCL1 pathway | p53 deletion results in a decrease of miR-16-1, leads to an increase expression of Mcl-1 in chronic lymphocytic leukemia. | Liu et al., 2014 |
| hsa-miR-17-92 cluster | Peripheral blood | Up | Toll-like receptor signaling pathway | miR-17-92 family regulates pro-survival and growth-promoting responses of chronic lymphocytic leukemia cells to TLR9 triggering. | Bomben et al., 2012 | |
| hsa-miR-15a | Peripheral blood | Down | TP53 | p53 signaling pathway | Over-expression of hsa-miR-15a suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis. | Fabbri et al, 2011 |
| hsa-miR-16-1 | Peripheral blood | Down | TP53 | p53 signaling pathway | Over-expression of hsa-miR-16-1 suppresses the expression of TP53 in B-cell chronic lymphocytic leukemia. A microRNA/TP53 feedback circuitry is associated with chronic lymphocytic leukemia pathogenesis. | Fabbri et al, 2011 |
| hsa-miR-34a | Peripheral blood | Up | p53 signaling pathway | MicroRNA-34a is proposed as a marker for the activity of the p53 signaling pathway in chronic lymphocytic leukemia. | Merkel et al., 2010 | |
| hsa-miR-15a | Peripheral blood | Down | BCL2 | Apoptosis pathway | miR-15a downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia. | Cimmino et al., 2005 |
| hsa-miR-16-1 | Peripheral blood | Down | BCL2 | Apoptosis pathway | miR-16-1 downregulates the expression of BCL2 and promotes apoptosis in chronic lymphocytic leukemia. | Cimmino et al., 2005 |