| Micro RNA | Tissue/ Cell line | MicroRNA regulation | Targeted Member | Pathway | More Details | References |
|---|---|---|---|---|---|---|
| hsa-miR-622 | Colorectum | Down | K RAS | RAS signaling pathway | MicroRNA-622 suppresses colorectal cancer occurrence and metastasis by down-regulating the expression of K-Ras. | Fang et al., 2016 |
| hsa-miR-140 | HCT 116 | SMAD2 | TGF-beta signaling pathway | Hsa-miR-140 inhibits colorectal carcinoma progression and metastasis through the down-regulation of Smad2, a key player in theTGF-beta signaling pathway. | Zhai et al., 2015 | |
| hsa-miR-375 | HCT 116 | BCL 2 | BCL-2 pathway | MicroRNA-375 acts as a key player in regulating the pathways responsible for inhibiting the natural history of colorectal cancer tumor cells, through the Bcl-2 pathway. | Zaharie et al., 2015 | |
| hsa-miR-140 | HCT 116 | Down | SMAD2 | TGF-beta signaling pathway | hsa-miR-140 inhibit CRC progression and metastasis by directly targeting Smad2 which is a key element inTGF-beta signaling pathway. | Zhai et al., 2015 |
| hsa-miR-371 | HCT 116, SW620, SW480, HT-29 | Down | SOX2 | Wnt signaling pathway | Down-regulation of SOX17 in CRC cells induces the low expression level of miR-371, which targets SOX2 leading to activation of Wnt signaling pathway. hsa-miR-371 acts as oncosuppressor in colorectal cancer progression. | Li et al., 2015 |
| hsa-miR-29c | SW620, LoVo | Down | GNA13 | Beta-catenin pathway | miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating GNA13. | Zhang et al., 2014 |
| hsa-miR-29c | SW620, LoVo | Down | PTP4A | Beta-catenin pathway | miR-29c regulates epithelial-to-mesenchymal transition in colorectal cancer via beta-catenin signaling by downregulating PTP4A. | Zhang et al., 2014 |
| hsa-miR-451 | HeLa, HUVEC, RKO | Down | IL6R | IL6R pathway | MicroRNA-451 function as a tumor suppressor by down-regulating the IL6R pathway. | Liu et al., 2014 |